Part of a series on the
COVID-19 pandemic
Scientifically accurate atomic model of the external structure of SARS-CoV-2. Each "ball" is an atom.
COVID-19 (disease) SARS-CoV-2 (virus) Cases Deaths
Timeline 2019 2020 January responses February responses March responses April responses May responses June responses July responses August responses September responses October responses November responses December responses 2021 January responses February responses March responses April responses May responses June responses July responses August responses September responses October responses November responses December responses 2022 January responses February responses March responses April responses May responses June responses July responses August responses September responses October responses November December 2023 2024
Locations By country and territory Africa Antarctica Asia Europe North America Oceania South America By conveyance Cruise ships Naval ships
International response Endemic phase Evacuations Face masks International aid Origin Lockdowns by country Misinformation by governments Fake treatments Social distancing Software Travel United Nations World Health Organization WTO IP waiver Undercounting of deaths COVID-19 apps Zero-COVID National responses Africa China European Union Germany Ghana India Ireland Netherlands New Zealand Nigeria Philippines Russia Sweden UK government US federal government Vietnam
Medical response Disease testing Breathalyzer Development Drug development Drug repurposing Public health mitigation Vaccines History Research VITT Deployment Authorizations Operation Warp Speed Misinformation and hesitancy US Vaccine card Vaccine passports Current vaccines CoronaVac Covaxin Convidecia Janssen Medigen Moderna Novavax Oxford–AstraZeneca Pfizer–BioNTech Sinopharm BIBP Sputnik V
Variants Variants of concern Alpha Beta Gamma Delta Omicron Other variants Epsilon Zeta Eta Theta Iota Kappa Lambda Mu Cluster 5 Lineage B.1.617
Economic impact and recession Arts and culture Aviation Cannabis Cinema films Disney Fashion Financial markets Food industry Food security Journalism Music Performing arts Retail Shipping Television US sportscasting programs Tourism Video games By country Canada India Ireland Malaysia New Zealand Russia UK US By sport Association football Baseball Basketball Combat sports Cricket Disc golf Gaelic games Gridiron football Ice hockey Motorsport Rugby league
Impacts Animals Alzheimer's disease patients Black people Crime Death rates by country Disability Domestic violence Emergency evacuations Education Female Environment Hospitals Language LGBT community Long-term care Media coverage Mental health symptoms Migration Military Notable deaths Other health issues Politics diplomacy Popular culture Protests Pregnancy Prisons Religion Catholic Church Hajj Science and technology Social media Strikes Suicides Telehealth Xenophobia and racism Society Ireland Malaysia New Zealand Russia UK US
COVID-19 portal

COH04S1 is a covid vaccine developed by the City of Hope Medical Center. This vaccine targets patients who are immunocompromised; immunocompromised patients have often shown a weak antibody response to past COVID-19 vaccines. COH04S1 is also targeted on people who are at a high risk of COVID-19 complications. The City of Hope Medical Center strives to make a better option than the current EUA and FDA approved vaccines, which are not working as well on this group of individuals.

The group leading the investigation of the vaccine is led by scientists named Felix Wussow with a Ph.D. , Flavia Chiuppesi with a Ph.D. as well, them both City of Hope assistant research professors in the Department of Hematology & Hematopoietic Cell Transplantation. The leader is named Don J. Diamond, Ph.D.: professor in the Department of Hematology & Hematopoietic Cell Transplantation at City of Hope. The vaccine is the first to study the safety and effectiveness in patients that have received a bone marrow transplant or chimeric antigen receptor therapy. It is also the first to look at the differences between the Pfizer vaccine with one that accommodates people who are receiving immunosuppressive therapy.

Previous COVID-19 vaccines in blood cancer patients show a high probability that 1 out of 4 blood cancer patients fail to produce antibodies. COH04S1 hopes to lower the chances of failure in producing antibodies in blood cancer patients.

This vaccine is built on a FDA-approved platform known as modified vaccinia ankara, also known as MVA. This platform has famously been used safely worldwide and effectively in cancer and transplant patients.

Phase 1 Trial

The vaccine has presently passed a phase 1 trial with healthy volunteers between the ages of 18 and 55 who have not had COVID-19. The vaccine aims to make the immune system produce antibodies as well as make the body produce T cells that provide long-term protection against future outbreaks. They first developed a MVA delivery vehicle, to keep the genetic components for a compound at a molecular level. SARS-CoV-2 and nucleocapsid proteins were injected into the platform for it to replicate DNA within cells, which would trigger the strong reproduction of T cells as well as potent antibodies against the virus. MVA vaccines are proven to produce an immune response within 14 days with only mild side effects.

The trial patients would have received two shots with 28 days in between, not knowing whether either of them were placebos or not.

Phase 2 Trial

COH04S1 is currently the only COVID-19 vaccine to pass onto phase 2 trials in cancer patients. This vaccine does not grow or reproduce in the human body, making it fit for stem cell transplant and CAR T patients. The volunteers will be closely monitored soon after the trial as well as a check up a year after the trial.

City of Hope accepted blood cancer patients who received a bone marrow transplant, or a CAR T cell therapy at least three months before volunteering, as well as meeting other requirements.

References

Marquez L (11 May 2022). "Phase 2 Trial Opens for City of Hope's Novel COVID-19 Vaccine". City of Hope. Retrieved 18 May 2022.