The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.[1][2] The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.[3]

Calpohostin R1 R2
Calphostin A Bz Bz
Calphostin B Bz H
Calphostin C Bz 4-(HO)Bz
Calphostin D H H
Calphostin I 4-(HO)Bz 4-(HO)Bz

Calphostin C

Calphostin C is a potent inhibitor of protein kinase C (PKC).

References

  1. ↑ Kobayashi, E; Ando, K; Nakano, H; Iida, T; Ohno, H; Morimoto, M; Tamaoki, T (1989). "Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities". J. Antibiot. 42 (10): 1470–1474. doi:10.7164/antibiotics.42.1470. PMID 2478514.
  2. ↑ Iida, T; Kobayashi, E; Yoshida, M; Sano, H (1989). "Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures". J. Antibiot. 42 (10): 1475–1481. doi:10.7164/antibiotics.42.1475. PMID 2478515.
  3. ↑ Calphostin C (UCN-1028C) at Biomol
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