DUSP1
Identifiers
AliasesDUSP1, CL100, HVH1, MKP-1, MKP1, PTPN10, dual specificity phosphatase 1
External IDsOMIM: 600714 MGI: 105120 HomoloGene: 3254 GeneCards: DUSP1
Orthologs
SpeciesHumanMouse
Entrez

1843

19252

Ensembl

ENSG00000120129

ENSMUSG00000024190

UniProt

P28562

P28563

RefSeq (mRNA)

NM_004417

NM_013642

RefSeq (protein)

NP_004408

NP_038670

Location (UCSC)Chr 5: 172.77 – 172.77 MbChr 17: 26.72 – 26.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.[5][6]

Function

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.[7]

Interactions

DUSP1 has been shown to interact with MAPK14,[8][9] MAPK1[9][10] and MAPK8.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000120129 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024190 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Keyse SM, Emslie EA (Oct 1992). "Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase". Nature. 359 (6396): 644–7. Bibcode:1992Natur.359..644K. doi:10.1038/359644a0. PMID 1406996. S2CID 4307895.
  6. ↑ Martell KJ, Kwak S, Hakes DJ, Dixon JE, Trent JM (Jul 1994). "Chromosomal localization of four human VH1-like protein-tyrosine phosphatases" (PDF). Genomics. 22 (2): 462–4. doi:10.1006/geno.1994.1411. hdl:2027.42/31442. PMID 7806236.
  7. ↑ "Entrez Gene: DUSP1 dual specificity phosphatase 1".
  8. ↑ Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". The Journal of Biological Chemistry. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. PMID 11359773.
  9. 1 2 3 Slack DN, Seternes OM, Gabrielsen M, Keyse SM (May 2001). "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". The Journal of Biological Chemistry. 276 (19): 16491–500. doi:10.1074/jbc.M010966200. PMID 11278799.
  10. ↑ Calvisi DF, Pinna F, Meloni F, Ladu S, Pellegrino R, Sini M, Daino L, Simile MM, De Miglio MR, Virdis P, Frau M, Tomasi ML, Seddaiu MA, Muroni MR, Feo F, Pascale RM (Jun 2008). "Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma". Cancer Research. 68 (11): 4192–200. doi:10.1158/0008-5472.CAN-07-6157. PMID 18519678.

Further reading


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