Exosome component 1

EXOSC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC1, CGI-108, CSL4, Csl4p, SKI4, Ski4p, hCsl4p, p13, Exosome component 1, PCH1F
External IDs	OMIM: 606493 MGI: 1913833 HomoloGene: 9359 GeneCards: EXOSC1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	97,446,017 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	41,921,862 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; body of pancreas; ; monocyte; ; anterior pituitary; ; body of stomach; ; prefrontal cortex; ; spleen; ; lymph node; ; canal of the cervix; ; smooth muscle tissue;
	Top expressed in
	morula; ; otic placode; ; secondary oocyte; ; interventricular septum; ; Paneth cell; ; internal carotid artery; ; abdominal wall; ; maxillary prominence; ; external carotid artery; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	exoribonuclease activity; protein binding; RNA binding;
Cellular component	cytoplasm; cytosol; nuclear exosome (RNase complex); nucleolus; exosome (RNase complex); nucleoplasm; nucleus;
Biological process	regulation of mRNA stability; exonucleolytic catabolism of deadenylated mRNA; rRNA processing; RNA phosphodiester bond hydrolysis, exonucleolytic; RNA processing;
	Sources:Amigo / QuickGO
Orthologs
	51013
	66583
	ENSG00000171311
	ENSMUSG00000034321
	Q9Y3B2
	Q9DAA6
NM_016046; NM_001318362; NM_001318363; NM_001318364; NM_001318365;
	NM_001318366
	NM_001164561; NM_025644; NM_001320231; NM_001320232; NM_001320233
NP_001305291; NP_001305292; NP_001305293; NP_001305294; NP_001305295;
	NP_057130
	NP_001158033; NP_001307160; NP_001307161; NP_001307162; NP_079920
	Wikidata
View/Edit Human	View/Edit Mouse

3'-5' exoribonuclease CSL4 homolog is an enzyme that in humans is encoded by the EXOSC1 gene.^[5]^[6]^[7]

This gene encodes a core component of the exosome complex. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46.^[7]

Interactions

Exosome component 1 has been shown to interact with:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171311 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034321 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J Mol Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
↑ Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
1 2 "Entrez Gene: EXOSC1 exosome component 1".
1 2 3 Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. PMID 12419256.

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
van Hoof A, Staples RR, Baker RE, Parker R (2000). "Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA". Mol. Cell. Biol. 20 (21): 8230–43. doi:10.1128/MCB.20.21.8230-8243.2000. PMC 86432. PMID 11027292.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. hdl:2066/186951. PMID 11110791.
Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171311 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034321 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11812149-5] 1 2 3 Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J Mol Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.

[pmid11719186-6] Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.

[entrez-7] 1 2 "Entrez Gene: EXOSC1 exosome component 1".

[pmid12419256-8] 1 2 3 Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. PMID 12419256.

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Interactions

References

Further reading