Exosome component 6

EXOSC6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC6, EAP4, MTR3, Mtr3p, hMtr3p, p11, Exosome component 6
External IDs	OMIM: 606490 MGI: 1919794 HomoloGene: 12469 GeneCards: EXOSC6
Gene location (Human)
Chr.	Chromosome 16 (human)
End	70,251,940 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	111,784,296 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; postcentral gyrus; ; Brodmann area 46; ; superior frontal gyrus; ; middle temporal gyrus; ; Achilles tendon; ; entorhinal cortex; ; pons; ; external globus pallidus;
	Top expressed in
	embryo; ; morula; ; vasculature; ; temporal lobe; ; amygdala; ; spinal cord; ; brain stem; ; choroid plexus; ; meninges; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	exoribonuclease activity; RNA binding;
Cellular component	cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); cytoplasmic exosome (RNase complex); nucleolus; nucleus; nucleoplasm;
Biological process	regulation of mRNA stability; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; rRNA 3'-end processing; rRNA catabolic process; DNA deamination; nuclear mRNA surveillance; exonucleolytic catabolism of deadenylated mRNA; U4 snRNA 3'-end processing; polyadenylation-dependent snoRNA 3'-end processing; rRNA processing; positive regulation of isotype switching; isotype switching; RNA phosphodiester bond hydrolysis, exonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	118460
	72544
	ENSG00000223496
	ENSMUSG00000109941
	Q5RKV6
	Q8BTW3
	NM_058219
	NM_028274
	NP_478126
	NP_082550
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome complex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene.^[5]^[6]^[7]

This gene product constitutes one of the subunits of the multisubunit particle called the exosome complex, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.^[7]

Interactions

Exosome component 6 has been shown to interact with Exosome component 7,^[6]Exosome component 8^[6] and Exosome component 1.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000223496 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000109941 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
1 2 3 4 Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J Mol Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
1 2 "Entrez Gene: EXOSC6 exosome component 6".

Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
van Hoof A, Parker R (2002). "Messenger RNA degradation: beginning at the end". Curr. Biol. 12 (8): R285–7. doi:10.1016/S0960-9822(02)00802-3. PMID 11967169. S2CID 17142692.
Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. hdl:2066/186951. PMID 11110791.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000223496 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000109941 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11719186-5] Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.

[pmid12419256-6] 1 2 3 4 Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J Mol Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.

[entrez-7] 1 2 "Entrez Gene: EXOSC6 exosome component 6".

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[3]

[4]

[5]

[6]

[7]

Interactions

References

Further reading