GABRA1
Identifiers
AliasesGABRA1, ECA4, EIEE19, EJM, EJM5, gamma-aminobutyric acid type A receptor alpha1 subunit, gamma-aminobutyric acid type A receptor subunit alpha1, DEE19
External IDsOMIM: 137160 MGI: 95613 HomoloGene: 629 GeneCards: GABRA1
Orthologs
SpeciesHumanMouse
Entrez

2554

14394

Ensembl

ENSG00000022355

ENSMUSG00000010803

UniProt

P14867

P62812

RefSeq (mRNA)

NM_010250
NM_001359035

RefSeq (protein)

NP_000797
NP_001121115
NP_001121116
NP_001121117
NP_001121120

NP_034380
NP_001345964

Location (UCSC)Chr 5: 161.85 – 161.9 MbChr 11: 42.02 – 42.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene.[5]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[6]

The GABRA1 receptor is the specific target of the z-drug class of nonbenzodiazepine hypnotic agents and is responsible for their hypnotic and hallucinogenic effects.

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000022355 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000010803 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Johnson KJ, Sander T, Hicks AA, van Marle A, Janz D, Mullan MJ, Riley BP, Darlison MG (Dec 1992). "Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis". Genomics. 14 (3): 745–748. doi:10.1016/S0888-7543(05)80178-8. PMID 1330891.
  6. "Entrez Gene: GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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