GP5
Identifiers
AliasesGP5, CD42d, GPV, glycoprotein V platelet
External IDsOMIM: 173511 MGI: 1096363 HomoloGene: 74523 GeneCards: GP5
Orthologs
SpeciesHumanMouse
Entrez

2814

14729

Ensembl

ENSG00000178732

ENSMUSG00000047953

UniProt

P40197

O08742
Q9QZU3

RefSeq (mRNA)

NM_004488

NM_008148

RefSeq (protein)

NP_004479

NP_032174

Location (UCSC)Chr 3: 194.39 – 194.4 MbChr 16: 30.13 – 30.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycoprotein V (platelet) (GP5) also known as CD42d (Cluster of Differentiation 42d), is a human gene.[5]

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 193400) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder.[supplied by OMIM][5]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000178732 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047953 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: GP5 glycoprotein V (platelet)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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