Illustration of HLA-B with bound peptide
major histocompatibility complex (human), class I, B82
Alleles B*8201
Structure (See HLA-B)
Symbol(s) HLA-B
Locus chr.6 6p21.31

HLA-B*82 (B*82) is an HLA-B allele-group. There is no current useful serotyping for HLA-B*82 gene products.[1] B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele.,[2] later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.[3]

Serotype

B82 serotype recognition of Some HLA B*82 allele-group gene products[4]
B*82B82 otherSample
allele % %size (N)
*8201379146

Allele frequencies

HLA B*8201 frequencies
freq
ref.Population(%)
[5]Luo (Kenya)1.9
[5]Guinea Bissau0.8
[5]Natal Zulu (S. Africa)0.5
[5]Beti (Cameroon)0.3
[5]Kenya0.3
[5]Kampala (Uganda)0.3
[5]Nandi (Kenya)0.2
'
HLA B**8202 frequencies
[5]Sudanese2.5
[5]Kenya0.7
[5]Guraiat and Hail (Saudi Arabia)0.2

References

  1. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  2. ↑ Hurley CK, Steiner N, Hoyer RJ, et al. (1996). "Novel HLA-B alleles, B*8201, B*3515 and B*5106, add to the complexity of serologic identification of HLA types". Tissue Antigens. 47 (3): 179–87. doi:10.1111/j.1399-0039.1996.tb02538.x. PMID 8740766.
  3. ↑ Cox ST, Hossain E, McWhinnie A, Prokupek B, Madrigal JA, Little AM (2000). "HLA-B*8202 identified in a Caucasoid potential bone marrow donor". Tissue Antigens. 56 (2): 188–91. doi:10.1034/j.1399-0039.2000.560216.x. PMID 11019925.
  4. ↑ derived from IMGT/HLA
  5. 1 2 3 4 5 6 7 8 9 10 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. {{cite journal}}: External link in |title= (help)
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