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| Aliases | NPB, L7, PPL7, PPneuropeptide B | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 607996 MGI: 2387153 HomoloGene: 102151 GeneCards: NPB | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.[5][6] It is expressed throughout the CNS with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000183979 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044034 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–41. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
- ↑ Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46. pp. 239–56. doi:10.1007/400_2007_056. ISBN 978-3-540-78350-3. PMID 18204824.
External links
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