Fetal viability is the ability of a human fetus to survive outside the uterus. Medical viability is generally considered to be between 23 and 24 weeks gestational age.[1][2] Viability depends upon factors such as birth weight, gestational age, and the availability of advanced medical care. In low-income countries, half of newborns born at or below 32 weeks gestational age died due to a lack of medical access; in high-income countries, the vast majority of newborns born above 24 weeks gestational age survive.[3]

As of 2022, the world record for the lowest gestational age newborn to survive is held by Curtis Zy-Keith Means, who was born on 5 July 2020 in the United States, at 21 weeks and 1 day gestational age, weighing 420 grams.[4]

Definitions

Viability, as the word has been used in the United States constitutional law since Roe v. Wade, is the potential of the fetus to survive outside the uterus after birth, natural or induced, when supported by up-to-date medicine. Fetal viability depends largely on the fetal organ maturity, and environmental conditions.[5] According to Websters Encyclopedic Unabridged Dictionary of the English Language, viability of a fetus means having reached such a stage of development as to be capable of living, under normal conditions, outside the uterus. Viability exists as a function of biomedical and technological capacities, which are different in different parts of the world. As a consequence, there is, at the present time, no worldwide, uniform gestational age that defines viability.[6]

According to the McGraw-Hill medical dictionary a nonviable fetus is "an expelled or delivered fetus which, although living, cannot possibly survive to the point of sustaining life independently, even with support of the best available medical therapy."[7] A legal definition states: "Nonviable means not capable of living, growing, or developing and functioning successfully. It is the antithesis of viable, which is defined as having attained such form and development of organs as to be normally capable of living outside the uterus." [Wolfe v. Isbell, 291 Ala. 327, 329 (Ala. 1973)][8]

Various jurisdictions have different legal definitions of viability. In Ireland, under the Health (Regulation of Termination of Pregnancy) Act 2018, fetal viability is defined as "the point in a pregnancy at which, in the reasonable opinion of a medical practitioner, the foetus is capable of survival outside the uterus without extraordinary life-sustaining measures." [Definitions (Part 2)(8)][9]

Black's law dictionary 6th edition

Viability. Capable of living. A term used to denote the power a newborn child possesses of continuing its independent existence. That stage of fetal development when the life of the unborn child may be continued indefinitely outside the womb by natural or artificial life-support systems. The constitutionality of this statutory definition (V.A.M.S. (Mo.),188.015) was upheld in Planned Parenthood of Central Mo. v. Danforth, 428 U.S. 52,96 S.Ct 2831, 49 L.Ed.2d 788.

For purposes of abortion regulation, viability is reached when, in the judgement of the attending physician on the particular facts of the case before her, there is a reasonable likelihood of the fetuses' sustained survival outside the womb, with or without artificial support. Colautti v. Franklin, 439 U.S. 379,388, 99 S.Ct. 675, 682, 58 L.Ed.2d 596. See Also Viable; Viable Child.

Medical viability

Fetal viability is generally considered to begin at 23 or 24 weeks gestational age in the United States.[10][11]

There is no sharp limit of development, gestational age, or weight at which a human fetus automatically becomes viable.[12] According to one study, between 2013 and 2018 at United States academic medical centers, the percentage of newborns who survived long enough to leave the hospital was 30% at 22 weeks, 55% at 23 weeks, 70% at 24 weeks, and 80% of those born at 25 weeks gestational age.[13] Between 2010 and 2014, babies in the United States had an approximately 70% survival rate when born under weight of 500 g (1.10lb), an increase from a 30.8% survival rate between 2006 and 2010.[14] A baby's chances for survival increases 3 to 4 percentage points per day between 23 and 24 weeks of gestation, and about 2 to 3 percentage points per day between 24 and 26 weeks of gestation. After 26 weeks the rate of survival increases at a much slower rate because survival is high already.[15] Prognosis depends also on medical protocols on whether to resuscitate and aggressively treat a very premature newborn, or whether to provide only palliative care, in view of the high risk of severe disability of very preterm babies.[16]

Stages in prenatal development, showing viability and point of 50% chance of survival (limit of viability) at bottom. Weeks and months numbered by gestation,

According to a Stanford University study on babies born in the most advanced US hospitals between 2013 and 2018, at 23 weeks, 55% of infants survive a preterm birth long enough to be discharged from the hospital, usually months later.[13] Most of these infants experienced some form of significant neurodevelopmental impairment, such as cerebral palsy.[13] Most were re-hospitalized for respiratory illnesses or other medical problems during the first two years of life.[13] Some used adaptive equipment such as walkers or feeding tubes, but most could feed themselves when they were 2 years old.[13] Most had typical vision and hearing.[13]

Completed weeks of gestation at birth 21 and less222324252627 283034
Chance of long-term survival with advanced medical care <1%[17]30%[13]55%[13]70%[13]80%[13]88%[13]90%[13] 95%[13]>95%>98%

Period of viability

Beliefs about viability vary by country. Medical decisions regarding the resuscitation of extremely preterm infants (EPI) deemed to be in the "grey zone" usually take into account weight and gestational age, as well as parental views.[18][19][20][21] One 2018 study showed that there was a significant difference between countries in what was considered to be the "grey zone": the "grey zone" was considered to be 22 to 23 weeks in Sweden, 23 to 24 weeks in the UK, and 24 to 26 weeks in the Netherlands.[18] Whether the fetus is in the period of viability may have legal ramifications as far as the fetus' rights of protection are concerned.[22] Traditionally, the period of viability referred to the period after the twenty-eighth week.[23]

Indian Law considers the period of viability to be the period after 28 weeks of gestational age.[24]

United States Supreme Court

The United States Supreme Court stated in Roe v. Wade (1973) that viability, defined as the "interim point at which the fetus becomes ... potentially able to live outside the mother's womb, albeit with artificial aid",[25] "is usually placed at about seven months (28 weeks) but may occur earlier, even at 24 weeks."[25] The 28-week definition became part of the "trimester framework" marking the point at which the "compelling state interest" (under the doctrine of strict scrutiny) in preserving potential life became possibly controlling, permitting states to freely regulate and even ban abortion after the 28th week.[25] The subsequent Planned Parenthood v. Casey (1992) modified the "trimester framework", permitting the states to regulate abortion in ways not posing an "undue burden" on the right of the mother to an abortion at any point before viability; on account of technological developments between 1973 and 1992, viability itself was legally dissociated from the hard line of 28 weeks, leaving the point at which "undue burdens" were permissible variable depending on the technology of the time and the judgement of the state legislatures.

Born-Alive Infants Protection Act of 2002

In 2002, the U.S. government enacted the Born-Alive Infants Protection Act. Whereas a fetus may be viable or not viable in utero, this law provides a legal definition for personal human life when not in utero. It defines "born alive" as "the complete expulsion or extraction from his or her mother of that member, at any stage of development, who after such expulsion or extraction breathes or has a beating heart, pulsation of the umbilical cord, or definite movement of voluntary muscles"[26] and specifies that any of these is the action of a living human person. While the implications of this law for defining viability in medicine may not be fully explored,[27] in practice doctors and nurses are advised not to resuscitate such persons with gestational age of 22 weeks or less, under 400 g weight, with anencephaly, or with a confirmed diagnosis of trisomy 13 or 18.[28][29]

U.S. state laws

Forty-three states have laws banning post-viability abortions unless pregnancy threatens the life or health of the woman or there is a fetal abnormality. Some allow doctors to decide for themselves if the fetus is viable. Some require doctors to perform tests to prove a fetus is pre-viable and require multiple doctors to certify the findings. The procedure intact dilation and extraction (IDX) became a focal point in the abortion debate,[30] based on the belief that it is used mainly post-viability.[31] IDX was made illegal in most circumstances by the Partial-Birth Abortion Ban Act in 2003, which the U.S. Supreme Court upheld in the case of Gonzales v. Carhart.

Limit of viability

The limit of viability is the gestational age at which a prematurely born fetus/infant has a 50% chance of long-term survival outside its mother's womb. With the support of neonatal intensive care units, the limit of viability in the developed world has declined since the 1960s.[32][33]

As of the mid-2000s, the limit of viability is considered to be around 24 weeks, although the incidence of major disabilities remains high at this point.[34][35] Neonatologists generally would not provide intensive care at 23 weeks, but would from 26 weeks.[36][34][37]

Different jurisdictions have different policies regarding the resuscitation of extremely premature newborns, that may be based on various factors such as gestational age, weight and medical presentation of the baby, the desires of parents and medical practitioners. The high risk of severe disability of very premature babies or of mortality despite medical efforts lead to ethical debates over quality of life and futile medical care, but also about the sanctity of life as viewed in various religious doctrines.[38]

As of 2022, the world record for the lowest gestational age newborn to survive is held by Curtis Zy-Keith Means, who was born on 5 July 2020 in the United States, at 21 weeks and 1 day gestational age, weighing 420 grams.[4]

A preterm birth, also known as premature birth, is defined as babies born alive before 37 weeks of pregnancy are completed.[39] There are three types of preterm births: extremely preterm (less than 28 weeks), very preterm (28 to 32 weeks) and moderate to late preterm (32 to 37 weeks).[39]

Factors that influence the chance of survival

There are several factors that affect the chance of survival of the baby. Two notable factors are age and weight. The baby's gestational age (number of completed weeks of pregnancy) at the time of birth and the baby's weight (also a measure of growth) influence whether the baby will survive. Another major factor is gender: male infants have a slightly higher risk of dying than female infants,[40] for which various explanations have been proposed.[41]

Several types of health problems also influence fetal viability. For example, breathing problems, congenital abnormalities or malformations, and the presence of other severe diseases, especially infection, threaten the survival of the neonate.

Other factors may influence survival by altering the rate of organ maturation or by changing the supply of oxygen to the developing fetus.

The mother's health plays a significant role in the child's viability. Diabetes in the mother, if not well controlled, slows organ maturation; infants of such mothers have a higher mortality. Severe high blood pressure before the 8th month of pregnancy may cause changes in the placenta, decreasing the delivery of nutrients and/or oxygen to the developing fetus and leading to problems before and after delivery.

Rupture of the fetal membranes before 24 weeks of gestation with loss of amniotic fluid markedly decreases the baby's chances of survival, even if the baby is delivered much later.[15]

The quality of the facility—whether the hospital offers neonatal critical care services, whether it is a Level I pediatric trauma care facility, the availability of corticosteroids and other medications at the facility, the experience and number of physicians and nurses in neonatology and obstetrics and of the providers has a limited but still significant impact on fetal viability. Facilities that have obstetrical services and emergency rooms and operating facilities, even if smaller, can be used in areas where higher services are not available to stabilize the mother and fetus or neonate until they can be transferred to an appropriate facility.[42][43][44][45]

See also

References

  1. ↑ "Fetal viability is at the center of Mississippi abortion case. Here's why". Washington Post. 2021-12-01. Retrieved 2022-07-24.
  2. ↑ Taylor, Derrick Bryson (2022-05-03). "Quick Facts You Should Know About Roe v. Wade". The New York Times. ISSN 0362-4331. Retrieved 2022-07-24.
  3. ↑ "Preterm birth". www.who.int. Retrieved 2022-07-24.
  4. 1 2 "Most premature baby". Guinness World Records. 5 July 2020. Retrieved 2022-07-23.
  5. ↑ "Fetal Viability". 2012. Archived from the original on 5 October 2018. Retrieved 15 November 2012.
  6. ↑ Breborowicz GH (January 2001). "Limits of fetal viability and its enhancement". Early Pregnancy. 5 (1): 49–50. PMID 11753511.
  7. ↑ The Free Dictionary. "nonviable fetus". Medical Dictionary. Retrieved May 21, 2019.
  8. ↑ "Non-Viable Fetus Law and Legal Definition". USLegal. Retrieved May 21, 2019.
  9. ↑ "Health (Regulation of Termination of Pregnancy) Act 2018" (PDF). Irish parliament.
  10. ↑ Liptak A (2021-11-28). "Fetal Viability, Long an Abortion Dividing Line, Faces a Supreme Court Test". The New York Times. ISSN 0362-4331. Retrieved 2022-05-08.
  11. ↑ Hassan A (2021-10-28). "What to Know About the Mississippi Abortion Law Challenging Roe v. Wade". The New York Times. ISSN 0362-4331. Retrieved 2021-11-11.
  12. ↑ Moore K, Persaud T (2003). The Developing Human: Clinically Oriented Embryology. Saunders. p. 103. ISBN 978-0-7216-6974-8.
  13. 1 2 3 4 5 6 7 8 9 10 11 12 13 Bell EF, Hintz SR, Hansen NI, Bann CM, Wyckoff MH, DeMauro SB, et al. (January 2022). "Mortality, In-Hospital Morbidity, Care Practices, and 2-Year Outcomes for Extremely Preterm Infants in the US, 2013-2018". JAMA. 327 (3): 248–263. doi:10.1001/jama.2021.23580. PMC 8767441. PMID 35040888.
  14. ↑ Varga P, Berecz B, Pete B, Kollár T, Magyar Z, Jeager J, et al. (June 2018). "Trends in Mortality and Morbidity in Infants Under 500 Grams Birthweight: Observations from Our Neonatal Intensive Care Unit (NICU)". Medical Science Monitor. 24: 4474–4480. doi:10.12659/MSM.907652. PMC 6055514. PMID 29956691.
  15. 1 2 "What are the chances that my baby will survive?". Archived from the original on 2018-08-09. Retrieved 14 November 2012.
  16. ↑ Verlato G, Gobber D, Drago D, Chiandetti L, Drigo P (January 2004). "Guidelines for resuscitation in the delivery room of extremely preterm infants". Journal of Child Neurology. 19 (1): 31–34. doi:10.1177/088307380401900106011. PMID 15032380. S2CID 20200767.
  17. ↑ "World's most premature baby defies sub-1% survival odds to break record". Guinness World Records. 10 November 2021. Retrieved 2022-03-15.
  18. 1 2 Wilkinson D, Verhagen E, Johansson S (September 2018). "Thresholds for Resuscitation of Extremely Preterm Infants in the UK, Sweden, and Netherlands". Pediatrics. 142 (Suppl 1): S574–S584. doi:10.1542/peds.2018-0478I. PMC 6379058. PMID 30171144.
  19. ↑ Li Z, Zeki R, Hilder L, Sullivan, EA (2012). "Australia's Mothers and Babies 2010". Perinatal statistics series no. 27. Cat. no. PER 57. Australian Institute of Health and Welfare National Perinatal Statistics Unit, Australian Government. Retrieved 4 July 2013.
  20. ↑ Mohangoo AD, Blondel B, Gissler M, Velebil P, Macfarlane A, Zeitlin J (2013). Wright L (ed.). "International comparisons of fetal and neonatal mortality rates in high-income countries: should exclusion thresholds be based on birth weight or gestational age?". PLOS ONE. 8 (5): e64869. Bibcode:2013PLoSO...864869M. doi:10.1371/journal.pone.0064869. PMC 3658983. PMID 23700489.
  21. ↑ Royal College of Obstetricians; Gynaecologists UK (April 2001). "Further Issues Relating to Late Abortion, Fetal Viability and Registration of Births and Deaths". Royal College of Obstetricians and Gynaecologists UK. Archived from the original on 5 November 2013. Retrieved 4 July 2013.
  22. ↑ "Attorney Catherine Christophillis Discusses The Reasoning Behind The Drug Testing Of Pregnant Women". Legal News Chat Transcript. October 25, 2000.
  23. ↑ Finney PA (1922). Moral Problems in Hospital Practice: a Practical Handbook. St. Louis: Herder Bk. Co. p. 24. OCLC 14054441.
  24. ↑ "IMA issues guidelines on fetal viability". India Today. Retrieved 2023-03-11.
  25. 1 2 3 Roe v. Wade, 410 U.S. 113, 160, 93 S.Ct. 705, 730 (1973).
  26. ↑ "House Report 107-186 - Born-Alive Infants Protection Act of 2001". frwebgate.access.gpo.gov. Retrieved 3 April 2018.
  27. ↑ Sayeed SA (October 2005). "Baby doe redux? The Department of Health and Human Services and the Born-Alive Infants Protection Act of 2002: a cautionary note on normative neonatal practice". Pediatrics. 116 (4): e576–e585. doi:10.1542/peds.2005-1590. PMID 16199687.
  28. ↑ Powell T (2012). "Decisions and Dilemmas Related to Resuscitation of Infants Born on the Verge of Viability". Newborn and Infant Nursing Reviews. 12 (1): 27–32. doi:10.1053/j.nainr.2011.12.004. Retrieved 8 October 2015.
  29. ↑ Kattwinkel J, Perlman JM, Aziz K, Colby C, Fairchild K, Gallagher J, et al. (November 2010). "Neonatal resuscitation: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care". Pediatrics. 126 (5): e1400–e1413. doi:10.1542/peds.2010-2972E. PMID 20956432.
  30. ↑ Finer LB, Henshaw SK (January 2003). "Abortion incidence and services in the United States in 2000". Perspectives on Sexual and Reproductive Health. 35 (1): 6–15. doi:10.1363/3500603. PMID 12602752.
  31. ↑ Foer F (1997). "Fetal Viability". Slate. Retrieved 14 November 2012.
  32. ↑ Santhakumaran S, Statnikov Y, Gray D, Battersby C, Ashby D, Modi N (May 2018). "Survival of very preterm infants admitted to neonatal care in England 2008-2014: time trends and regional variation". Archives of Disease in Childhood. Fetal and Neonatal Edition. 103 (3): F208–F215. doi:10.1136/archdischild-2017-312748. PMC 5916099. PMID 28883097.
  33. ↑ Walsh F (11 April 2008). "Prem baby survival rates revealed". BBC News. Retrieved 2008-05-11.
  34. 1 2 Kaempf JW, Tomlinson M, Arduza C, Anderson S, Campbell B, Ferguson LA, et al. (January 2006). "Medical staff guidelines for periviability pregnancy counseling and medical treatment of extremely premature infants". Pediatrics. 117 (1): 22–29. doi:10.1542/peds.2004-2547. PMID 16396856. S2CID 20495326.
  35. ↑ Morgan MA, Goldenberg RL, Schulkin J (February 2008). "Obstetrician-gynecologists' practices regarding preterm birth at the limit of viability". The Journal of Maternal-Fetal & Neonatal Medicine. 21 (2): 115–121. doi:10.1080/14767050701866971. PMID 18240080. S2CID 27735824.
  36. ↑ Vavasseur C, Foran A, Murphy JF (September 2007). "Consensus statements on the borderlands of neonatal viability: from uncertainty to grey areas". Irish Medical Journal. 100 (8): 561–564. PMID 17955714. All would provide intensive care at 26 weeks and most would not at 23 weeks. The grey area is 24 and 25 weeks gestation. This group of infants constitute 2 per 1000 births.
  37. ↑ Roe v. Wade, 410 U.S. 113 (1973) ("viability is usually placed at about seven months (28 weeks) but may occur earlier, even at 24 weeks.") Retrieved 2007-03-04.
  38. ↑ "Critical care decisions in fetal and neonatal medicine: ethical issues: a guide to the Report" (PDF). Nuffield Council on Bioethics. London, England. 2007.
  39. 1 2 "Preterm birth". World Health Organization. Retrieved 3 April 2018.
  40. ↑ Morse SB, Wu SS, Ma C, Ariet M, Resnick M, Roth J (January 2006). "Racial and gender differences in the viability of extremely low birth weight infants: a population-based study". Pediatrics. 117 (1): e106–e112. doi:10.1542/peds.2005-1286. PMID 16396844.
  41. ↑ DiPietro JA, Voegtline KM (February 2017). "The gestational foundation of sex differences in development and vulnerability". Neuroscience. 342: 4–20. doi:10.1016/j.neuroscience.2015.07.068. PMC 4732938. PMID 26232714. Proposed mechanisms include:
    1. Male fetuses mature slower than female fetuses, and thus have prolonged vulnerability. [...]
    2. The uterus is less hospitable to male fetuses than it is to female fetuses. [...]
    3. Prenatal sex steroids differentially affect the intrauterine environment and developing fetal brain. [...]
    4. From an evolutionary biology standpoint, male and female fetuses may rely on different adaptation strategies to maximize survival early in life.
  42. ↑ "NIH Study Reveals Factors That Influence Premature Infant Survival, Disability" (Press release). NIH. April 16, 2008. Retrieved February 29, 2020.
  43. ↑ Glass HC, Costarino AT, Stayer SA, Brett CM, Cladis F, Davis PJ (June 2015). "Outcomes for extremely premature infants". Anesthesia and Analgesia. 120 (6): 1337–1351. doi:10.1213/ANE.0000000000000705. PMC 4438860. PMID 25988638.
  44. ↑ Behrman RE, Butler AS, eds. (3 April 2018). "Mortality and Acute Complications in Preterm Infants". Preterm Birth: Causes, Consequences, and Prevention. National Academies Press (US). Retrieved 3 April 2018.
  45. ↑ Belluck P (6 May 2015). "Premature Babies May Survive at 22 Weeks if Treated, Study Finds". The New York Times. Retrieved 3 April 2018.

Further reading

  • "Fetal Viability and Death" (PDF). United States. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. May 2006.
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