The Escherichia coli chromosome shows two main levels of global organization, macrodomains and replichores.[1] In E. coli chromosomes, the origin and terminus of replication divide the genome into oppositely replicated halves called replichores. Replichore 1, which is replicated clockwise, has the presented strand of E. coli as its leading strand; in replichore 2 the complementary strand is the leading one. Many features of E. coli are oriented with respect to replication.[2]

References

  1. ↑ Lesterlin C, Mercier R, Boccard F, Barre FX, Cornet F (June 2005). "Roles for replichores and macrodomains in segregation of the Escherichia coli chromosome". EMBO Rep. 6 (6): 557–62. doi:10.1038/sj.embor.7400428. PMC 1369093. PMID 15891766.
  2. ↑ Blattner FR, Plunkett G, Bloch CA, et al. (September 1997). "The complete genome sequence of Escherichia coli K-12". Science. 277 (5331): 1453–62. doi:10.1126/science.277.5331.1453. PMID 9278503.

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