| SRL | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | SRL, entrez:6345, sarcalumenin, SAR | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604992 MGI: 2146620 HomoloGene: 45500 GeneCards: SRL | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Sarcalumenin is a protein that in humans is encoded by the SRL gene.[5][6]
Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle.[7] Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins.[8] Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity.[7] Sarcalumenin is a calcium-binding glycoprotein composed of 473 acidic amino acids with a molecular weight of 160 KDa. Together along with other luminal calcium buffer proteins, sarcalumenin plays an important role in regulation of calcium uptake and release during excitation-contraction coupling (ECC) in muscle fibers.
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000185739 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022519 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Leberer E, Charuk JH, Green NM, MacLennan DH (August 1989). "Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum". Proceedings of the National Academy of Sciences of the United States of America. 86 (16): 6047–51. Bibcode:1989PNAS...86.6047L. doi:10.1073/pnas.86.16.6047. PMC 297772. PMID 2762314.
- ↑ Lanfranchi G, Muraro T, Caldara F, Pacchioni B, Pallavicini A, Pandolfo D, Toppo S, Trevisan S, Scarso S, Valle G (January 1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Research. 6 (1): 35–42. doi:10.1101/gr.6.1.35. PMID 8681137.
- 1 2 Jiao Q, Bai Y, Akaike T, Takeshima H, Ishikawa Y, Minamisawa S (August 2009). "Sarcalumenin is essential for maintaining cardiac function during endurance exercise training". American Journal of Physiology. Heart and Circulatory Physiology. 297 (2): H576-82. doi:10.1152/ajpheart.00946.2008. PMC 2724216. PMID 19502553.
- ↑ Yoshida M, Minamisawa S, Shimura M, Komazaki S, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Saeki Y, Ishikawa Y, Yanagisawa T, Takeshima H (February 2005). "Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice". The Journal of Biological Chemistry. 280 (5): 3500–6. doi:10.1074/jbc.M406618200. PMID 15569689.
External links
- sarcalumenin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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