Snake H/ACA box small nucleolar RNA
HACA_sno_Snake
Identifiers
SymbolHACA_sno_Snake
RfamRF00098
Other data
RNA typeGene;snRNA;snoRNA;H/ACA-box;
PDB structuresPDBe

In molecular biology, Snake H/ACA box small nucleolar RNA refers to a number of very closely related non-coding RNA (ncRNA) genes identified in snakes which have been predicted to be small nucleolar RNAs (snoRNAs). This type of ncRNA is involved in the biogenesis of other small nuclear RNAs and are often referred to as 'guide' RNAs. They are usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.

These snoRNA genes were initially identified in the introns of the cardiotoxin 4 and cobrotoxin genes of the Taiwan cobra (Bungarus multicinctus) and the Taiwan banded krait (Bungarus multicinctus) during sequencing of these genes.[1][2] These snoRNAs are predicted to act as H/ACA box type methylation guides as they have the predicted hairpin-hinge-hairpin-tail structure and extended regions of complementarity to 5S ribosomal RNA (rRNA).[3]

References

  1. ↑ Chang, Long-Sen; Lin, Shu-Kai; Wu, Pei-Fung (17 April 1998). "Differentially expressed snoRNAs in Bungarus multicinctus (Taiwan banded krait)". Biochemical and Biophysical Research Communications. 245 (2): 397–402. doi:10.1006/bbrc.1998.8433. PMID 9571162.
  2. ↑ Chang, Long-Sen; Hong, Enjong (30 July 1997). "Novel SnoRNAs from Naja naja atra (Taiwan cobra) and Bungarus multicinctus (Taiwan banded krait) form extended sequence complementarity to 5S rRNA". Biochemical and Biophysical Research Communications. 236 (3): 782–784. doi:10.1006/bbrc.1997.7049. PMID 9245733.
  3. ↑ Ganot, Philippe; Caizergues-Ferrer, Michèle; Kiss, Tamás (1 April 1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes & Development. 11 (7): 941–956. doi:10.1101/gad.11.7.941. PMID 9106664.


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