优降宁
优降宁是不可逆、选择性的单胺氧化酶抑制剂(MAO-A和MAO-B的IC50分别为11.52 nM和8.20 nM)。[1][2]1963年,它由雅培以抗高血压药的形式进入美国及英国市场,商品名Eutonyl。同样于1960年代进入市场的单胺氧化酶抑制剂还有尼亚拉胺、异卡波肼、苯乙肼、反苯环丙胺。[3]:146[4]:60[5][6]优降宁于2007年被停用。[7]它除了作为单胺氧化酶抑制剂,也会与单胺氧化酶的别构中心I2咪唑啉受体结合。[8]
臨床資料 | |
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MedlinePlus | a682088 |
ATC碼 | |
识别 | |
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CAS号 | 555-57-7 |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.008.275 |
化学 | |
化学式 | C11H13N |
摩尔质量 | 159.23 g·mol−1 |
3D模型(JSmol) | |
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参见
- 氯吉兰
- 雷沙吉兰
- 司来吉兰
参考资料
- Fisar Z, Hroudová J, Raboch J. . Neuro Endocrinol Lett. 2010, 31 (5): 645–56. PMID 21200377.
- Murphy DL, Karoum F, Pickar D, et al. . . Journal of Neural Transmission. Supplement 52. 1998: 39–48. ISBN 978-3-211-83037-6. PMID 9564606. doi:10.1007/978-3-7091-6499-0_5.
|journal=
被忽略 (帮助) - Edward Shorter, A historical dictionary of psychiatry. Oxford University Press, Inc 2005. ISBN 0195176685
- William M. Wardell and Louis Lasagna. Regulation Drug Development (Evaluative Studies 21) American Enterprise Institute (1975) ISBN 0844731676
- Council on Drugs New Drugs and Developments in Therapeutics: Pargyline Hydrochloride (Eutonyl) JAMA. 1963;184(11):887. doi:10.1001/jama.1963.03700240079013.
- . Drug and Therapeutics Bulletin. 15 November 1963, 1 (15): 59–60. ISSN 1755-5248. S2CID 220162992. doi:10.1136/dtb.1.15.59 (英语).
Pargyline is promoted only for the treatment of hypertension, and not for depression.
- W. Steven Pray. . www.medscape.com. 2007.
- . CRC Press. 1995: 43.
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