依他唑酯
依他唑酯(英语:Etazolate,开发代号:SQ-20,009、EHT-0202),也叫乙酰腙吡唑啶,是一种抗焦虑药物,是吡唑并吡啶衍生物,具有独特的药理特性。[1][2][3]它作为巴比妥结合位点GABAA受体的正向变构调节剂、[4][5][6][7]A1和A2亚型的腺苷拮抗剂[8]以及对PDE4同工型具有选择性的磷酸二酯酶抑制剂。[9][10][11]该药物目前正处于治疗阿尔茨海默病的临床试验中。[12]
臨床資料 | |
---|---|
给药途径 | 口服 |
ATC碼 |
|
法律規範狀態 | |
法律規範 |
|
识别 | |
| |
CAS号 | 51022-77-6 |
PubChem CID | |
IUPHAR/BPS | |
ChemSpider | |
UNII | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
化学 | |
化学式 | C14H19N5O2 |
摩尔质量 | 289.34 g·mol−1 |
3D模型(JSmol) | |
| |
|
参考资料
- Hall JA, Morton I. . Kluwer Academic. 1999. ISBN 0-7514-0499-3.
- Williams M. . Journal of Medicinal Chemistry. May 1983, 26 (5): 619–628. PMID 6132997. doi:10.1021/jm00359a001.
- Williams M, Risley EA. . Life Sciences. February 1979, 24 (9): 833–841. PMID 449623. doi:10.1016/0024-3205(79)90367-9.
- Zezula J, Slany A, Sieghart W. . European Journal of Pharmacology. April 1996, 301 (1–3): 207–214. PMID 8773466. doi:10.1016/0014-2999(96)00066-0.
- Davies MF. . Remington G, Baskys A (编). . Boca Raton: CRC Press. 1996. ISBN 0-8493-8386-2.
- Olsen RW, Gordey M. . Mishina M, Kurachi Y (编). . Handbook of Experimental Pharmacology 147. Berlin: Springer. 2000: 499–517. ISBN 3-540-66127-1. doi:10.1007/978-3-642-57083-4_19.
- Olsen RW. . Jucker E (编). 31. Boston: Birkhauser. 1987: 526. ISBN 3-7643-1837-6.
- Williams M, Jarvis MF. . Pharmacology, Biochemistry, and Behavior. February 1988, 29 (2): 433–441. PMID 3283781. S2CID 35635747. doi:10.1016/0091-3057(88)90182-7.
- Chasin M, Harris DN, Phillips MB, Hess SM. . Biochemical Pharmacology. September 1972, 21 (18): 2443–2450. PMID 4345859. doi:10.1016/0006-2952(72)90414-5.
- Wang P, Myers JG, Wu P, Cheewatrakoolpong B, Egan RW, Billah MM. . Biochemical and Biophysical Research Communications. May 1997, 234 (2): 320–324. PMID 9177268. doi:10.1006/bbrc.1997.6636.
- Daniel JL. . Gresele P (编). . Cambridge, UK: Cambridge University Press. 2002. ISBN 0-521-80261-X.
- . Pipeline. ExonHit. (原始内容存档于2011-01-11).
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.