别孕烷醇酮

别孕烷醇酮英語:ALLO,也名为3α,5α-孕烷醇酮)是一种作用于大脑的神经甾体[2][3],可用于治疗产后抑郁症[3][4][5]

别孕烷醇酮
Skeletal formula of allopregnanolone
Ball-and-stick model of the allopregnanolone molecule
臨床資料
商品名Zulresso
其他名稱ALLO; Allo; ALLOP; AlloP; Brexanolone; SAGE-547; SGE-102; 5α-Pregnan-3α-ol-20-one; 3α-Hydroxy-5α-pregnan-20-one; 3α,5α-Tetrahydroprogesterone; 3α,5α-THP
给药途径Intravenous infusion[1]
藥物類別Neurosteroids; Antidepressants
法律規範狀態
法律規範
  • 处方药(-only)
藥物動力學數據
血漿蛋白結合率>99%[1]
药物代谢Non-CYP450 (keto-reduction via AKRs, glucuronidation via UGTs, sulfation via SULTs)[1]
生物半衰期9 hours[1]
排泄途徑Feces: 47%[1]
Urine: 42%[1]
识别
  • 1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
    OR
    1-[(1S,2S,5R,7S,10R,11S,14S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-14-yl]ethanone
CAS号516-54-1
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
化学
化学式C21H34O2
摩尔质量318.501 g/mol
3D模型(JSmol
  • CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)C
  • InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1
  • Key:AURFZBICLPNKBZ-SYBPFIFISA-N

参考文献

  1. (PDF). [2019-05-26]. (原始内容存档 (PDF)于2020-11-12).
  2. Reddy DS. . Progress in Brain Research 186. 2010: 113–37. ISBN 9780444536303. PMC 3139029可免费查阅. PMID 21094889. doi:10.1016/B978-0-444-53630-3.00008-7. |journal=被忽略 (帮助)
  3. Commissioner, Office of the. . www.fda.gov. [21 March 2019]. (原始内容存档于2019-04-22) (英语).
  4. Frieder A, Fersh M, Hainline R, Deligiannidis KM. . CNS Drugs. March 2019, 33 (3): 265–282. PMID 30790145. doi:10.1007/s40263-019-00605-7.
  5. Wilkinson ST, Sanacora G. . Drug Discov. Today. February 2019, 24 (2): 606–615. PMID 30447328. doi:10.1016/j.drudis.2018.11.007.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.