妥拉唑啉

妥拉唑啉是非选择性竞争性α受体拮抗剂。[1]它是治疗周边血管痉挛（如手足发绀）的血管扩张剂，也能与硝普钠配合解除25I-NBOMe[2]、布苯丙胺、Bromodragonfly[3][4]等5-HT2A受体激动剂过量造成的严重血管收缩，避免坏疽。不过，它最常用作消除甲苯噻嗪镇静作用的兽药。[5][6]

妥拉唑啉
臨床資料
AHFS/Drugs.com国际药品名称
给药途径IV
ATC碼
识别
  • 2-Benzyl-4,5-dihydro-1H-imidazole
CAS号59-98-3  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.408
化学
化学式C10H12N2
摩尔质量160.22 g·mol−1
3D模型（JSmol）
  • N\1=C(\NCC/1)Cc2ccccc2
  • InChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12) checkY
  • Key:JIVZKJJQOZQXQB-UHFFFAOYSA-N checkY

参考资料
  1. Aronson, J. K. . Amsterdam: Elsevier Science. 2016. ISBN 978-0-444-53717-1. OCLC 927102885. Tolazoline is an α2 adrenoceptor antagonist that increases skin blood flow in healthy subjects and has been used to relieve acute vasospasm.
  2. . hmdb.ca. [2022-02-03].
  3. Bowen JS, Davis GB, Kearney TE, Bardin J. . JAMA. March 1983, 249 (11): 1477–9. PMID 6827726. doi:10.1001/jama.1983.03330350053028.
  4. Thorlacius K, Borna C, Personne M. . Läkartidningen. 2008, 105 (16): 1199–200. PMID 18522262 （瑞典语）.
  5. Boothe DM. . Adams HR (编). . Ames: Iowa State University Press. 2001: 378–9 [2008-09-08]. ISBN 0-8138-1743-9.
  6. Hall LW, Clarke KW, Trim CM. . . Philadelphia: W.B. Saunders. 2001: 90–1. ISBN 0-7020-2035-4.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.