美西林
美西林(INN:Mecillinam;USAN:Amdinocillin)是一種广谱半合成青霉素[2],對革兰氏阴性菌作用强,也可用來治療傷寒和副伤寒[3][4]。其口服利用率很差,匹美西林則是針對此缺陷開發出來的。[5]
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| 臨床資料 | |
|---|---|
| 商品名 | Coactin, Leo, Selexid, Selexidin |
| AHFS/Drugs.com | 国际药品名称 |
| 懷孕分級 |
|
| 给药途径 | 靜脈注射、肌肉注射 |
| ATC碼 | |
| 法律規範狀態 | |
| 法律規範 |
|
| 藥物動力學數據 | |
| 生物利用度 | 可忽略 |
| 血漿蛋白結合率 | 5-10% |
| 药物代谢 | 肝臟 |
| 生物半衰期 | 1-3小時 |
| 排泄途徑 | 腎、膽 |
| 识别 | |
| |
| CAS号 | 32887-01-7 |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.046.601 |
| 化学 | |
| 化学式 | C15H23N3O3S |
| 摩尔质量 | 325.426 g/mol |
| 3D模型(JSmol) | |
| |
這種藥物是荷蘭製藥公司“Leo Pharmaceutical Products”(今利奥制药)研發出來的,最初代號為FL 1060,1972年面世。[6][7]
參考文獻
- Nicolle LE. . J Antimicrob Chemother. August 2000, 46 (Suppl A): 35–39. PMID 10969050. doi:10.1093/jac/46.suppl_1.35.
- Neu HC. . Pharmacotherapy. 1985, 5 (1): 1–10. PMID 3885172. doi:10.1002/j.1875-9114.1985.tb04448.x.
- Clarke PD, Geddes AM, McGhie D, Wall JC. . Br Med J. July 1976, 2 (6026): 14–5. PMC 1687648
. PMID 820402. doi:10.1136/bmj.2.6026.14. - Geddes AM, Clarke PD. . J Antimicrob Chemother. July 1977,. 3 Suppl B: 101–2. PMID 408321. doi:10.1093/jac/3.suppl_b.101.
- Pham P, Bartlett JG. . Point-of-Care Information Technology ABX Guide. Johns Hopkins University. August 28, 2008 [2019-03-08]. (原始内容存档于2009-02-04). Retrieved on August 31, 2008. Freely available with registration.
- Lund F, Tybring L. . Nature New Biology. April 1972, 236 (66): 135–7. PMID 4402006. doi:10.1038/236135c0.
- Tybring L, Melchior NH. . Antimicrob Agents Chemother. September 1975, 8 (3): 271–6 [2019-03-08]. PMC 429305
. PMID 170856. doi:10.1128/aac.8.3.271. (原始内容存档于2019-12-14).
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