17α-羟孕烯醇酮

17α-羟孕烯醇酮英語:)是一种孕烷类(C21)甾体物质,由孕烯醇酮在C17的α位羟基化而来。体内的17α-羟孕烯醇酮由肾上腺生殖腺线粒体细胞色素P450氧化酶——17α-羟化酶(CYP17A1)氧化而来。人类体内的17α-羟孕烯醇酮在青春期末达到高峰,随后下降[1],在孕期也有较高浓度。

17α-羟孕烯醇酮
藥物動力學數據
药物代谢Adrenal, Gonads
识别
  • 3β,17α-dihydroxypregn-5-en-20-one
CAS号387-79-1  checkY
PubChem CID
ChemSpider
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard100.006.239
化学
化学式C21H32O3
摩尔质量332.48 g/mol
3D模型(JSmol
熔点268 °C(514 °F)
  • CC[C@@]2(O)CC[C@H]1[C@@H]3CCC4CC(O)C(=O)C[C@]4(C)[C@H]3CC[C@@]12C
  • InChI=1S/C21H34O3/c1-4-21(24)10-8-16-14-6-5-13-11-17(22)18(23)12-19(13,2)15(14)7-9-20(16,21)3/h13-17,22,24H,4-12H2,1-3H3/t13?,14-,15+,16+,17?,19+,20+,21-/m1/s1 checkY
  • Key:QPLFSAZMHUAMKE-FOCOMJRBSA-N checkY


另见

参考文献

  1. Hill, M; Lukác, D; Lapcík, O; Sulcová, J; Hampl, R; Pouzar, V; Stárka, L. . Clinical chemistry and laboratory medicine : CCLM / FESCC. 1999, 37 (4): 439–47. PMID 10369116. doi:10.1515/CCLM.1999.072.
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