4-羟基苯基丙酮

4-羟基苯基丙酮（）是苯基丙酮（苯丙胺在人体中的不活泼代谢产物）的羟基类似物。[1][2]当它作为苯丙胺的代谢产物出现时，它通常是由不活泼的代谢物苯基丙酮中直接产生。[1][3]

苯丙胺的代謝途徑[sources 1]
Graphic of several routes of amphetamine metabolism
4-Hydroxyamphetamine
4-Hydroxynorephedrine
Para-
Hydroxylation
Para-
Hydroxylation
Para-
Hydroxylation
Beta-
Hydroxylation
Beta-
Hydroxylation
Oxidative
Deamination
Oxidation
Glycine
Conjugation
图像顶端包含可点击的链接
人体中，4-羟基苯基丙酮是苯丙胺和苯基丙酮的代谢产物。
4-羟基苯基丙酮
IUPAC名
1-(4-Hydroxyphenyl)propan-2-one
别名 p-Hydroxyphenylacetone; para-Hydroxyphenylacetone
识别
CAS号 770-39-8
PubChem 7019274
ChemSpider 5382241
SMILES
 
  • CC(=O)CC1=CC=C(C=C1)O
InChI
 
  • 1S/C9H10O2/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,11H,6H2,1H3
InChIKey VWMVAQHMFFZQGD-UHFFFAOYSA-N
性质
化学式 C9H10O2
摩尔质量 150.17 g·mol−1
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

参注
  1. [3][4][5][6][7][8][9][10]

参考资料
  1. Santagati NA, Ferrara G, Marrazzo A, Ronsisvalle G. . J. Pharm. Biomed. Anal. September 2002, 30 (2): 247–55. PMID 12191709. doi:10.1016/S0731-7085(02)00330-8.
  2. . NCBI. PubChem Compound. [2013-10-25]. （原始内容存档于2014-01-08）.
  3. (PDF). United States Food and Drug Administration. Shire US Inc: 12–13. December 2013 [30 December 2013]. （原始内容存档 (PDF)于2018-07-18）.
  4. Glennon RA. . Lemke TL, Williams DA, Roche VF, Zito W (编). 7th. Philadelphia, USA: Wolters Kluwer Health/Lippincott Williams & Wilkins. 2013: 646–648 [2018-06-20]. ISBN 9781609133450. （原始内容存档于2020-07-26）.
  5. Taylor KB. (PDF). J. Biol. Chem. January 1974, 249 (2): 454–458 [6 November 2014]. PMID 4809526. （原始内容存档 (PDF)于2019-04-04）.
  6. Krueger SK, Williams DE. . Pharmacol. Ther. June 2005, 106 (3): 357–387. PMC 1828602 可免费查阅. PMID 15922018. doi:10.1016/j.pharmthera.2005.01.001.
    Table 5: N-containing drugs and xenobiotics oxygenated by FMO （页面存档备份，存于）
  7. Cashman JR, Xiong YN, Xu L, Janowsky A. . J. Pharmacol. Exp. Ther. March 1999, 288 (3): 1251–1260. PMID 10027866.
  8. Santagati NA, Ferrara G, Marrazzo A, Ronsisvalle G. . J. Pharm. Biomed. Anal. September 2002, 30 (2): 247–255. PMID 12191709. doi:10.1016/S0731-7085(02)00330-8.
  9. Sjoerdsma A, von Studnitz W. . Br. J. Pharmacol. Chemother. April 1963, 20: 278–284. PMC 1703637 可免费查阅. PMID 13977820. doi:10.1111/j.1476-5381.1963.tb01467.x.
  10. Badenhorst CP, van der Sluis R, Erasmus E, van Dijk AA. . Expert Opin. Drug Metab. Toxicol. September 2013, 9 (9): 1139–1153. PMID 23650932. doi:10.1517/17425255.2013.796929.

外部链接
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