AZD0328

AZD0328是一种开发中的药物，分子式C13H16N2O，是一种选择性的α7菸鹼興奮劑，会增强脑皮层的多巴胺释放，改善大鼠的学习和注意力过程[1]。

AZD0328
法律規範狀態
法律規範
  • Investigational
识别
  • 3′H‐4‐Azaspiro[bicyclo[2.2.2]octane‐2,2'‐furo[2,3‐b]pyridine]
CAS号220099-91-2  checkY
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
化学
化学式C13H16N2O
摩尔质量216.28 g·mol−1
3D模型（JSmol）
  • C1C2=CC=CN=C2OC11CN2CCC1CC2
  • InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1 checkY
  • Key:OCKIPDMKGPYYJS-ZDUSSCGKSA-N checkY

它可以3-奎宁环酮和2-氯吡啶为原料经多步反应制得。[2]

参考文献
  1. Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, et al. . Biochemical Pharmacology. October 2009, 78 (7): 880–8. PMID 19615981. doi:10.1016/j.bcp.2009.07.005.
  2. Loch, James, III; Mullen, George; Phillips, Eifion. Preparation of furopyridineamines as nicotinic receptor agonists. 2000. WO 2000042044 A1.
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