CDKN2BAS
CDKN2B-AS亦被称为ANRIL（INK4基因座中反义非编码RNA，英語：）是一条由19个外显子组成的长链非编码RNA，在基因组中横跨12.63万个碱基对，转录产物被剪接为长3834个碱基的RNA。该长链位于p15CDKN2B-p16CDKN2A-p14ARF基因座中且与蛋白编码基因呈反义方向转录。一些位于CDKN2B-AS的單核苷酸多態性位点（SNPs）改变其表达量，并与冠狀動脈性心臟病、糖尿病及多种癌症在内的许多疾病呈关联性[1]。该条长链与多梳抑制复合物1中的克罗莫框7（CBX7）及多梳抑制复合物2中的SUZ12相结合，并通过与这两种多梳蛋白相互作用引起其它基因转录沉默[2][3]。
| CDKN2B反义RNA 1 | |||||
|---|---|---|---|---|---|
| 标识 | |||||
| 代号 | CDKN2B-AS1; ANRIL; CDKN2B-AS; CDKN2BAS; NCRNA00089; p15AS | ||||
| 扩展标识 | 遗传学：613149 GeneCards: CDKN2B-AS1 Gene | ||||
| |||||
| 直系同源体 | |||||
| 物种 | 人类 | 小鼠 | |||
| Entrez | 100048912 | n/a | |||
| Ensembl | ENSG00000240498 | n/a | |||
| UniProt | n/a | n/a | |||
| mRNA序列 | NR_003529 | n/a | |||
| 蛋白序列 | n/a | n/a | |||
| 基因位置 |
Chr 9: 21.99 – 22.12 Mb | n/a | |||
| PubMed查询 | n/a | ||||
| CDKN2B反义RNA 1内含子保守区 | |
|---|---|
 | |
| CDKN2B-AS的预测二级结构与序列保守性 | |
| 识别符 | |
| 代号 | CDKN2B-AS |
| Alt.代号 | ANRIL |
| Rfam | RF01909 |
| 其他数据 | |
| RNA类型 | Gene; |
| 域 | Eukaryota; |
另见
参考文献
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