CXCL10

CXCL10
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1O80、1LV9、1O7Y、1O7Z
識別號
别名	CXCL10；, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
外部ID	OMIM：147310 MGI：1352450 HomoloGene：1203 GeneCards：CXCL10
基因位置（人类）
染色体	4號染色體[1]
终止	76,023,497 bp[1]
基因位置（小鼠）
染色体	小鼠5号染色体[2]
终止	92,496,748 bp[2]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 細胞因子活性; • heparin binding; • CXCR3 chemokine receptor binding; • chemokine activity; • 血浆蛋白结合; • cAMP-dependent protein kinase regulator activity; • signaling receptor binding; • chemoattractant activity;
細胞組分	• 細胞外區域; • external side of plasma membrane; • 細胞外空間; • 胞內;
生物學過程	• regulation of endothelial tube morphogenesis; • negative regulation of myoblast differentiation; • cellular response to heat; • response to vitamin D; • positive regulation of cell migration; • T cell chemotaxis; • chemokine-mediated signaling pathway; • cell-cell signaling; • response to virus; • muscle organ development; • positive regulation of monocyte chemotaxis; • positive regulation of release of sequestered calcium ion into cytosol; • endothelial cell activation; • positive regulation of cAMP-mediated signaling; • regulation of T cell chemotaxis; • blood circulation; • 趨化性; • positive regulation of leukocyte chemotaxis; • cell surface receptor signaling pathway; • response to lipopolysaccharide; • negative regulation of myoblast fusion; • defense response to virus; • regulation of cell population proliferation; • 免疫反应; • positive regulation of cell population proliferation; • response to auditory stimulus; • negative regulation of angiogenesis; • response to cold; • cellular response to lipopolysaccharide; • response to gamma radiation; • positive regulation of T cell migration; • 訊息傳遞; • positive regulation of transcription by RNA polymerase II; • regulation of protein kinase activity; • defense response; • inflammatory response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • cytokine-mediated signaling pathway; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • response to bacterium; • neutrophil chemotaxis; • leukocyte chemotaxis; • positive chemotaxis; • regulation of apoptotic process;
	Sources:Amigo / QuickGO
直系同源
	3627
	15945
	ENSG00000169245
	ENSMUSG00000034855
	P02778
	P17515
	NM_001565
	NM_021274
	NP_001556
	NP_067249
	維基數據

CXCL10（英語：）是一小分子的细胞因子属于CXC趋化因子家族[5]，又被称作“干扰素伽玛诱导的10千道尔顿蛋白”（10 kDa interferon-gamma-induced protein，IP-10）[6] 。干扰素伽玛可以在多种细胞（如巨噬细胞[7] ，单核细胞[7] ，内皮细胞[8]和成纤维细胞）中诱导CXCL10的表达。CXCL10的功能包括对T细胞和单核细胞的细胞趋化作用[9][10]，促进T细胞黏附于内皮细胞[8]，抗肿瘤[11]，及血管新生[8]。人类的CXCL10基因与CXCL9，CXCL11的基因相邻聚集在第四染色体上。CXCL10, CXCL9和CXCL11结合趋化因子受体 CXCR3而起其细胞趋化作用[9][10] 。

参见

参考文献

GRCh38: Ensembl release 89: ENSG00000169245 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034855 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.
Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.
Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.
Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.
Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65

外部链接

Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med. 2006 Feb 9;354(6):610-21.（页面存档备份，存于）

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169245 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034855 - Ensembl, May 2017

[3] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.

[6] Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.

[nor-7] Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.

[ang-8] Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.

[chemo-9] Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.

[fun-10] Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.

[11] Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65