CXCL11

CXCL11（英語：）是一小分子的细胞因子属于CXC趋化因子家族[1]，又被称作“干扰素诱导的T细胞a趋化因子”（Interferon-inducible T-cell alpha chemoattractant (I-TAC)[1]。

Chemokine (C-X-C motif) ligand 11
PDB rendering based on 1rjt.
有效结构
PDB 直系同源检索：PDBe, RCSB
标识
代号 CXCL11; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B; b-R1
扩展标识 遗传学：604852 鼠基因：1860203 同源基因：3944 GeneCards: CXCL11 Gene
RNA表达模式
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 6373 56066
Ensembl ENSG00000169248 n/a
UniProt O14625 Q9JHH5
mRNA序列 NM_005409 NM_019494.1
蛋白序列 NP_005400 NP_062367.1
基因位置 Chr 4:
76.95 – 76.96 Mb		 n/a
PubMed查询


表达

在白细胞，胰腺和肝脏中表达水平高，在胸腺，脾和肺有中等水平的表达，在小肠，胎盘和前列腺中表达水平低[1]。干扰素伽玛和干扰素－b可以在单核细胞[1]，支气管上皮细胞[2]，中性粒细胞[3]，角质形成细胞[4]，和内皮细胞诱导CXCL11的表达。


受体

CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用[1][5][6]。CXCL11也可以结合到趋化因子受体CCR3上而阻止CCR3配体的结合[7]。


功能

CXCL11对活化的T细胞，中性粒细胞和单核细胞有细胞趋化作用[1]。

参见

参考文献
  1. Cole et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 187: 2009-2021, 1998.
  2. Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K., Garcia-Zepeda, E. A., Hamid, Q., Luster, A. D. (1999) The T cell-specific CXC chemokines IP-10, MIG, and I-TAC are expressed by activated human bronchial epithelial cells J. Immunol. 162,3549-3558
  3. Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L., Olsen, H., Murphy, M., Liao, F., Farber, J., Cassatella, M. A. (1999) Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils J. Immunol. 162,4928-4937.
  4. Tensen, C. P., Flier, J., Van Der Raaij-Helmer, E. M., Sampat-Sardjoepersad, S., Van Der Schors, R. C., Leurs, R., Scheper, R. J., Boorsma, D. M., Willemze, R. (1999) Human IP-9: a keratinocyte-derived high-affinity CXC-chemokine ligand for the IP-10/MIG receptor (CXCR3) J. Invest. Dermatol. 112,716-72.
  5. Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
  6. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
  7. Loetscher P, Pellegrino A, Gong JH, Mattioli I, Loetscher M, Bardi G, Baggiolini M, Clark-Lewis I. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3. J Biol Chem. 2001 Feb 2;276(5):2986-91

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