R13 (药物)

R13是一种小分子黄酮类化合物药物，可口服给药[1]，是脑源性神经营养因子的受体——Trk受体B（TrkB）的选择性激动剂，用于阿茲海默症的治疗[2]。

R13
臨床資料
其他名稱4-Oxo-2-phenyl-4H-chromene-7,8-diyl bis(methylcarbamate)
给药途径口服给药[1]
藥物動力學數據
代謝產物7,8-二羟基黄酮[1]
识别
  • [8-(Methylcarbamoyloxy)-4-oxo-2-phenylchromen-7-yl] N-methylcarbamate
CAS号1609067-49-3  checkY
PubChem CID
UNII
化学
化学式C19H16N2O6
摩尔质量368.35 g·mol−1
3D模型（JSmol）
  • CNC(=O)OC1=C(C2=C(C=C1)C(=O)C=C(O2)C3=CC=CC=C3)OC(=O)NC
  • InChI=1S/C19H16N2O6/c1-20-18(23)26-14-9-8-12-13(22)10-15(11-6-4-3-5-7-11)25-16(12)17(14)27-19(24)21-2/h3-10H,1-2H3,(H,20,23)(H,21,24)
  • Key:NWWRHMSYZTWUBD-UHFFFAOYSA-N

参考文献
  1. Chen C, Wang Z, Zhang Z, Liu X, Kang SS, Zhang Y, Ye K. . Proc. Natl. Acad. Sci. U.S.A. January 2018, 115 (3): 578–583. PMC 5777001 可免费查阅. PMID 29295929. doi:10.1073/pnas.1718683115 可免费查阅.
  2. US application 20150274692,Keqiang Ye,「7,8-Dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto」,发表于2015-10-01,指定于Emory University

外部链接
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