S100蛋白
S100蛋白（英語：）是一种脊椎动物的低分子量蛋白质家族，具有两个碱性螺旋-环-螺旋的钙结合位点（EF手型）。已知有21种不同的S100蛋白[1]。编码这些蛋白的基因家族的基因以S100为前缀，如S100A1, S100A2, S100A3等。 这一家族的蛋白也被视为是损伤相关分子模式（Damage-associated molecular pattern，DAMP）的分子。
| S100/ICaBP type calcium binding domain | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 Structure of the S100B protein. Based on PyMOL rendering of PDB 1b4c. | |||||||||||
| 鑑定 | |||||||||||
| 標誌 | S_100 | ||||||||||
| Pfam | PF01023（旧版） | ||||||||||
| InterPro | IPR013787 | ||||||||||
| PROSITE | PDOC00275 | ||||||||||
| SCOP | 1cnp / SUPFAM | ||||||||||
| |||||||||||
相关的人类基因
- S100A1，S100A2，S100A3，S100A4，S100A5，S100A6，S100A7（银屑病素）， S100A8，S100A9（8和9的异二聚体称为钙卫蛋白），S100A10，S100A11，S100A12（钙粒蛋白C），S100A13，S100A14，S100A15（koebnerisin），S100A16
- S100B
- S100P[2][3]
参考文献
- Marenholz I, Heizmann CW, Fritz G. . Biochem. Biophys. Res. Commun. October 2004, 322 (4): 1111–22. PMID 15336958. doi:10.1016/j.bbrc.2004.07.096.
- Penumutchu, Srinivasa R.; Chou, Ruey-Hwang; Yu, Chin. . PLOS ONE. 2014-08-01, 9 (8): e103947 [2020-09-26]. ISSN 1932-6203. PMC 4118983
. PMID 25084534. doi:10.1371/journal.pone.0103947. （原始内容存档于2017-01-12）. - Penumutchu, Srinivasa R.; Chou, Ruey-Hwang; Yu, Chin. . Biochemical and Biophysical Research Communications. 2014-10-17, 454 (3): 404–409. ISSN 1090-2104. PMID 25450399. doi:10.1016/j.bbrc.2014.10.048.
延伸阅读
- Wolf R, Voscopoulos CJ, FitzGerald PC, et al. . J. Invest. Dermatol. 2006, 126 (7): 1600–8. PMID 16528363. doi:10.1038/sj.jid.5700210.
- Ronald Wolf, O. M. Zack Howard, Hui-Fang Dong, Christopher Voscopoulos, Karen Boeshans, Jason Winston, Rao Divi, Michele Gunsior, Paul Goldsmith, Bijan Ahvazi, Triantafyllos Chavakis, Joost J. Oppenheim and Stuart H. Yuspa. . The Journal of Immunology. 2010, 181 (2): 1499–1506.
- Ronald Wolf, Christopher Voscopoulos, Jason Winston, Alif Dharamsi, Paul Goldsmith Michele Gunsior, Barbara K. Vonderhaar, Melanie Olson, Peter H. Watson, and Stuart H. Yuspa. . J. Cancer Lett. 2008, 277 (1): 101–107. PMC 2680177 . PMID 19136201. doi:10.1016/j.canlet.2008.11.032.
- Ronald Wolf, Francesca Mascia, Alif Dharamsi, O. M. Zack Howard, Christophe Cataisson, Val Bliskovski, Jason Winston, Lionel Feigenbaum, Ulrike Lichti, Thomas Ruzicka Triantafyllos Chavakis, and Stuart H. Yuspa. . Science Translational Medicine. 2010, 2 (61): 61ra90. PMID 21148126. doi:10.1126/scitranslmed.3001108.