CatSper1, is a protein which in humans is encoded by the CATSPER1 gene.[5][6][7] CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[8]
Function
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.[9]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000175294 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038498 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Quill TA, Ren D, Clapham DE, Garbers DL (October 2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. Bibcode:2001PNAS...9812527Q. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
- ↑ Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE (October 2001). "A sperm ion channel required for sperm motility and male fertility". Nature. 413 (6856): 603–9. Bibcode:2001Natur.413..603R. doi:10.1038/35098027. PMC 8462998. PMID 11595941. S2CID 4424815.
- ↑ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
- ↑ "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- ↑ "Entrez Gene: CatSper1".
Further reading
- Li HG, Liao AH, Ding XF, et al. (2006). "The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa". Asian J. Androl. 8 (3): 301–6. doi:10.1111/j.1745-7262.2006.00132.x. PMID 16625279.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity". J. Biol. Chem. 281 (31): 22332–41. doi:10.1074/jbc.M511288200. PMID 16740636.
- Avenarius MR, Hildebrand MS, Zhang Y, et al. (2009). "Human Male Infertility Caused by Mutations in the CATSPER1 Channel Protein". Am. J. Hum. Genet. 84 (4): 505–10. doi:10.1016/j.ajhg.2009.03.004. PMC 2667975. PMID 19344877.
- Garbers DL (2001). "Ion channels. Swimming with sperm". Nature. 413 (6856): 579, 581–2. Bibcode:2001Natur.413..579G. doi:10.1038/35098164. PMID 11595929. S2CID 6099942.
- Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. Bibcode:2001PNAS...9812527Q. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
- Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nikpoor P, Mowla SJ, Movahedin M, et al. (2004). "CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility". Hum. Reprod. 19 (1): 124–8. doi:10.1093/humrep/deh043. PMID 14688170.
- Ren D, Navarro B, Perez G, et al. (2001). "A sperm ion channel required for sperm motility and male fertility". Nature. 413 (6856): 603–9. Bibcode:2001Natur.413..603R. doi:10.1038/35098027. PMC 8462998. PMID 11595941. S2CID 4424815.
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