KCNN4
Identifiers
AliasesKCNN4, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4, IK, DHS2, potassium calcium-activated channel subfamily N member 4
External IDsOMIM: 602754 MGI: 1277957 HomoloGene: 1696 GeneCards: KCNN4
Orthologs
SpeciesHumanMouse
Entrez

3783

16534

Ensembl

ENSG00000104783

ENSMUSG00000054342

UniProt

O15554

O89109

RefSeq (mRNA)

NM_002250

NM_001163510
NM_008433

RefSeq (protein)

NP_002241

NP_001156982
NP_032459

Location (UCSC)Chr 19: 43.77 – 43.78 MbChr 7: 24.07 – 24.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.[5]

Function

The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.[5]

History

The channel activity was first described in 1958 by György Gárdos in human erythrocytes.[6] The channel is also named Gardos channel because of its discoverer.

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000104783 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054342 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4".
  6. Gardos G (1958). "The function of calcium in the potassium permeability of human erythrocytes". Biochim. Biophys. Acta. 30 (3): 653–4. doi:10.1016/0006-3002(58)90124-0. PMID 13618284.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.