KCNMB3
Identifiers
AliasesKCNMB3, BKBETA3, HBETA3, K(VCA)BETA-3, KCNMB2, KCNMBL, SLO-BETA-3, SLOBETA3, potassium calcium-activated channel subfamily M regulatory beta subunit 3
External IDsOMIM: 605222 MGI: 3612244 HomoloGene: 18141 GeneCards: KCNMB3
Orthologs
SpeciesHumanMouse
Entrez

27094

100502876

Ensembl

ENSG00000171121

ENSMUSG00000091091

UniProt

Q9NPA1

E9Q7U0

RefSeq (mRNA)

NM_001163677
NM_014407
NM_171828
NM_171829
NM_171830

NM_001195074

RefSeq (protein)

NP_001157149
NP_055222
NP_741979
NP_741980
NP_741981

NP_001182003

Location (UCSC)Chr 3: 179.24 – 179.27 MbChr 3: 32.53 – 32.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium-activated potassium channel subunit beta-3 is a protein that in humans is encoded by the KCNMB3 gene.[5][6]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. At least four transcript variants encoding four different isoforms have been found for this gene.[6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171121 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000091091 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Riazi MA, Brinkman-Mills P, Johnson A, Naylor SL, Minoshima S, Shimizu N, Baldini A, McDermid HE (Feb 2000). "Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2". Genomics. 62 (1): 90–4. doi:10.1006/geno.1999.5975. PMID 10585773.
  6. 1 2 "Entrez Gene: KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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