Enzymes are listed here by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission (EC) numbering system:
Category:Oxidoreductases (EC 1) (Oxidoreductase)
Category:EC 1.1 (act on the CH-OH group of donors)
- Category:EC 1.1.1 (with NAD+ or NADP+ as acceptor)
- Alcohol dehydrogenase (NAD) EC 1.1.1.1
- Alcohol dehydrogenase (NADP) EC 1.1.1.2
- Homoserine dehydrogenase EC 1.1.1.3
- Aminopropanol oxidoreductase EC 1.1.1.4
- Diacetyl reductase EC 1.1.1.5
- Glycerol dehydrogenase EC 1.1.1.6
- Propanediol-phosphate dehydrogenase EC 1.1.1.7
- glycerol-3-phoshitiendopene dehydrogenase (NAD+) EC 1.1.1.8
- D-xylulose reductase EC 1.1.1.9
- L-xylulose reductase EC 1.1.1.10
- Lactate dehydrogenase EC 1.1.1.27
- Malate dehydrogenase EC 1.1.1.37
- Isocitrate dehydrogenase EC 1.1.1.42
- HMG-CoA reductase EC 1.1.1.88
- Category:EC 1.1.2 (with a cytochrome as acceptor)
- Category:EC 1.1.3 (with oxygen as acceptor)
- Category:EC 1.1.4 (with a disulfide as acceptor)
- Category:EC 1.1.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.1.99 (with other acceptors)
Category:EC 1.2 (act on the aldehyde or oxo group of donors)
Category:EC 1.3 (act on the CH-CH group of donors)
- Category:EC 1.3.1 (with NAD+ or NADP+ as acceptor)
- Category:EC 1.3.2 (with a cytochrome as acceptor)
- Category:EC 1.3.3 (with oxygen as acceptor)
- Category:EC 1.3.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.3.7 (with an iron–sulfur protein as acceptor)
- Category:EC 1.3.99 (with other acceptors)
Category:EC 1.4 (act on the CH-NH2 group of donors)
- Category:EC 1.4.3
Category:EC 1.5 (act on CH-NH group of donors)
- Category:EC 1.5.1 (with NAD+ or NADP+ as acceptor)
- Category:EC 1.5.3 (with oxygen as acceptor)
- Category:EC 1.5.4 (with a disulfide as acceptor)
- Category:EC 1.5.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.5.7 (with an iron–sulfur protein as acceptor)
- Category:EC 1.5.8 (with a flavin as acceptor)
- Category:EC 1.5.99 (with other acceptors)
Category:EC 1.6 (act on NADH or NADPH)
- Category:EC 1.6.1 (with NAD+ or NADP+ as acceptor)
- Category:EC 1.6.2 (with a cytochrome as acceptor)
- Category:EC 1.6.3 (with oxygen as acceptor)
- Category:EC 1.6.4 now Category:EC 1.8.1
- Category:EC 1.6.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.6.6 (with a nitrogenous group as acceptor)
- Category:EC 1.6.7 now Category:EC 1.18.1
- Category:EC 1.6.8 now Category:EC 1.5.1
- Category:EC 1.6.99 (with other acceptors)
Category:EC 1.7 (act on other nitrogenous compounds as donors)
- Category:EC 1.7.1 (with NAD+ or NADP+ as acceptor)
- Category:EC 1.7.2 (with a cytochrome as acceptor)
- Category:EC 1.7.3 (with oxygen as acceptor)
- Category:EC 1.7.7 (with an iron–sulfur protein as acceptor)
- Category:EC 1.7.99 (with other acceptors)
Category:EC 1.8 (act on a sulfur group of donors)
- Category:EC 1.8.1 (with NAD+ or NADP+ as acceptor)
- Category:EC 1.8.2 (with a cytochrome as acceptor)
- Category:EC 1.8.3 (with oxygen as acceptor)
- Category:EC 1.8.4 (with a disulfide as acceptor)
- Category:EC 1.8.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.8.6 deleted, included in EC 2.5.1.18
- Category:EC 1.8.7 (with an iron–sulfur protein as acceptor)
- Category:EC 1.8.98 (with other, known, acceptors)
- Category:EC 1.8.99 (with other acceptors)
Category:EC 1.9 (act on a heme group of donors)
- Category:EC 1.9.3 (with oxygen as acceptor)
- Category:EC 1.9.6 (with a nitrogenous as acceptor)
- Category:EC 1.9.99 transferred, now EC 1.9.98.1
Category:EC 1.10 (act on diphenols and related substances as donors)
- Category:EC 1.10.1(with NAD+ or NADP+ as acceptor)
- Category:EC 1.10.2 (with a cytochrome as acceptor)
- Category:EC 1.10.3 (with oxygen as acceptor)
- Category:EC 1.10.99 (with other acceptors)
Category:EC 1.11 (act on peroxide as an acceptor -- peroxidases)
Category:EC 1.12 (act on hydrogen as a donor)
- Category:EC 1.12.1 (with NAD+ or NADP+ as acceptor)
- Category:EC 1.12.2 (with a cytochrome as acceptor)
- Category:EC 1.12.5 (with a quinone or similar compound as acceptor)
- Category:EC 1.12.7 (with an iron–sulfur protein as acceptor)
- Category:EC 1.12.98 (with other known acceptors)
- Category:EC 1.12.99 (with other acceptors)
Category:EC 1.13 (act on single donors with incorporation of molecular oxygen)
- Category:EC 1.13.11 (With incorporation of two atoms of oxygen)
- Category:EC 1.13.12 (With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases))
Category:EC 1.14 (act on paired donors with incorporation of molecular oxygen)
- Cytochrome P450 oxidase
- Category:Cytochrome P450
- Category:EC 1.14.12
- Category:EC 1.14.13
- Category:EC 1.14.14
- Category:EC 1.14.16
- Category:EC 1.14.18
Category:EC 1.15 (act on superoxide radicals as acceptors)
- Category:EC 1.15.1
Category:EC 1.16 (oxidize metal ions)
- Category:EC 1.16.3
Category:EC 1.17 (act on CH or CH2 groups)
- Category:EC 1.17.1
- Category:EC 1.17.2
- Category:EC 1.17.3
- Category:EC 1.17.4
- Category:EC 1.17.5
- Category:EC 1.17.7
- Category:EC 1.17.99
Category:EC 1.18 (act on iron–sulfur proteins as donors)
- Category:EC 1.18.6
Category:EC 1.19 (act on reduced flavodoxin as donor)
- Category:EC 1.19.6
Category:EC 1.20 (act on phosphorus or arsenic as donors)
- Category:EC 1.20.1
- Category:EC 1.20.2
- Category:EC 1.20.4
- Category:EC 1.20.9
- Category:EC 1.20.99
Category:EC 1.21 (act on X-H and Y-H to form an X-Y bond)
- Category:EC 1.21.1
- Category:EC 1.21.3
- Category:EC 1.21.4
- Category:EC 1.21.99
Category:EC 1.97 (other oxidoreductases)
- Category:EC 1.97.1
Category:Transferases (EC 2) (Transferase)
Category:EC 2.1 (transfer one-carbon groups, Methylase)
- Category:EC 2.1.1
- Category:EC 2.1.3
Category:EC 2.2 (transfer aldehyde or ketone groups)
Category:EC 2.3 (acyltransferases)
- Category:EC 2.3.1
- Category:EC 2.3.2
Category:EC 2.4 (glycosyltransferases)
- Category:EC 2.4.2
Category:EC 2.5
- Category:EC 2.5.1
Category:EC 2.5 (transfer alkyl or aryl groups, other than methyl groups)
Category:EC 2.6 (transfer nitrogenous groups)
- Category:EC 2.6.1
Category:EC 2.7 (transfer phosphorus-containing groups)
- Category:EC 2.7.2
Category:EC 2.8 (transfer sulfur-containing groups)
- EC 2.8.1.1: Thiosulfate sulfurtransferase
- EC 2.8.1.2: 3-mercaptopyruvate sulfurtransferase
- EC 2.8.1.3: Thiosulfate—thiol sulfurtransferase
- EC 2.8.1.4: tRNA uracil 4-sulfurtransferase
- EC 2.8.1.5: Thiosulfate—dithiol sulfurtransferase
- EC 2.8.1.6: Biotin synthase
- EC 2.8.1.7: Cysteine desulfurase
- EC 2.8.1.8: Lipoyl synthase
- EC 2.8.1.9: Molybdenum cofactor sulfurtransferase
- EC 2.8.1.10: Thiazole synthase
- EC 2.8.1.11: Molybdopterin synthase sulfurtransferase
- EC 2.8.1.12: Molybdopterin synthase
- EC 2.8.1.13: tRNA-uridine 2-sulfurtransferase
- EC 2.8.1.14: tRNA-5-taurinomethyluridine 2-sulfurtransferase
- EC 2.8.1.15: tRNA-5-methyluridine(54) 2-sulfurtransferase
Category:EC 2.9 (transfer selenium-containing groups)
Category:Hydrolases (EC 3) (Hydrolase)
Category:EC 3.1 (act on ester bonds)
- Nuclease
- Endonuclease
- Exonuclease
- Category:EC 3.1.1
- Category:EC 3.1.2
- Category:EC 3.1.3
- Category:EC 3.1.4
- Category:EC 3.1.21
- Restriction enzyme Type 1 (EC 3.1.21.3)
- Restriction enzyme Type 2 (EC 3.1.21.4)
- Restriction enzyme Type 3 (EC 3.1.21.5)
- Restriction enzyme Type 4 (?)
- Deoxyribonuclease I (EC 3.1.21.1)
- Category:EC 3.1.26
- Category:EC 3.1.27
Category:EC 3.2 (act on sugars - glycosylases)
Function and clinical importance of some enzymes in category 3.2.1
Amylase
Function: Amylase is an enzyme that is responsible for the breaking of the bonds in starches, polysaccharides, and complex carbohydrates to be turned into simple sugars that will be easier to absorb.
Clinical Significance: Amylase also has medical history in the use of Pancreatic Enzyme Replacement Therapy (PERT). One of the components is Sollpura (liprotamase), which help in the breakdown of saccharides into simple sugars.
Lysozyme
Function: An enzyme that is produced by animals that forms part of the innate immune system and is abundant in the secretions of saliva, human milk, tears, and mucus. It functions as an antimicrobial agent by splitting the peptidoglycan component of bacterial cell walls, which then leads to cell death.
Clinical Significance: Toxic levels of blood are caused by the excessive production of lysozyme's by cancer cells. Lysozyme's have also been associated with Bronchopulmonary dysplasia (BPD) in newborns and is a key factor in providing the immunology of infants during breast feeding.
Sucrase
Function: Sucrase is a stomachs related protein that mobilizes hydrolysis to convert sucrose into glucose and fructose.
Clinical Significance: Low amounts of Sucrose also known as Sucrose intolerance happens when sucrose isn’t being discharged in the small digestive tract. A result of this is extra gas.
Lactase
Function: lactase is located in the small digestives system of people and other creatures such as mammals. Lactase is the bases of the total absorption of milk.
Clinical Significance: People who are lactose intolerant have medicine that can help with the digestion. When you are lactose intolerant you might experience gas, bloating, and pain along with other symptoms regarding your digestive system.
Category:EC 3.3 (act on ether bonds)
- Category:EC 3.3
- Adenosylmethionine hydrolase
- S-adenosyl-L-homocysteine hydrolase
- Alkenylglycerophosphocholine hydrolase
- Alkenylglycerophosphoethanolamine hydrolase
- Cholesterol-5,6-oxide hydrolase
- Hepoxilin-epoxide hydrolase
- Isochorismatase
- Leukotriene-A4 hydrolase
- Limonene-1,2-epoxide hydrolase
- Microsomal epoxide hydrolase
- Trans-epoxysuccinate hydrolase
Category:EC 3.4 (act on peptide bonds - Peptidase)
- Category:EC 3.4.11
- Category:EC 3.4.15
- Category:EC 3.4.21
- Serine protease
- Chymotrypsin (EC 3.4.21.1)
- Trypsin (EC 3.4.21.4)
- Thrombin (EC 3.4.21.5)
- Factor X (EC 3.4.21.6)
- Plasmin (EC 3.4.21.7)
- Acrosin (EC 3.4.21.10)
- Factor VII (EC 3.4.21.21)
- Factor IX (EC 3.4.21.22)
- Prolyl oligopeptidase (EC 3.4.21.26)
- Factor XI (EC 3.4.21.27)
- Elastase (EC 3.4.21.37)
- Factor XII (EC 3.4.21.38)
- Proteinase K (EC 3.4.21.64)
- Tissue plasminogen activator (EC 3.4.21.68)
- Protein C (EC 3.4.21.69)
- Category:EC 3.4.22
- Category:EC 3.4.23
- Category:EC 3.4.24
- Category:EC 3.4.25
Category:EC 3.5 (act on carbon–nitrogen bonds, other than peptide bonds)
- Category:EC 3.5.1 (In linear amides)
- Category:EC 3.5.2 (In cyclic amides)
- Category:EC 3.5.3 (In linear amidines)
- Category:EC 3.5.4 (In cyclic amidines)
- Category:EC 3.5.5 (In nitriles)
Category:EC 3.6 (act on acid anhydrides)
- Category:EC 3.6.1
- Category:EC 3.6.3
Category:EC 3.7 (act on carbon–carbon bonds)
Category:EC 3.8 (act on halide bonds)
- EC 3.8.1.3 Haloacetate dehalogenase
Category:EC 3.9 (act on phosphorus–nitrogen bonds)
- EC 3.9.1.1: Phosphoamidase
- EC 3.9.1.2: Protein arginine phosphatase
- EC 3.9.1.3: Phosphohistidine phosphatase
Category:EC 3.10 (act on sulfur–nitrogen bonds)
Category:EC 3.11 (act on carbon–phosphorus bonds)
Category:EC 3.12 (act on sulfur–sulfur bonds)
Category:EC 3.13 (act on carbon–sulfur bonds)
- EC 3.13.1.1: UDP-sulfoquinovose synthase
- EC 3.13.1.3: 2'-hydroxybiphenyl-2-sulfinate desulfinase
- EC 3.13.1.4: 3-sulfinopropanoyl—CoA desulfinase
- EC 3.13.1.5: Carbon disulfide hydrolase
- EC 3.13.1.6: (CysO sulfur-carrier protein)-S-L-cysteine hydrolase
- EC 3.13.1.7: Carbonyl sulfide hydrolase
- EC 3.13.1.8: S-adenosyl-L-methionine hydrolase (adenosine-forming)
Category:Lyases (EC 4) (Lyase)
Category:EC 4.1 (carbon–carbon lyases)
- Category:EC 4.1.1
- Category:EC 4.1.2
Category:EC 4.2 (carbon–oxygen lyases)
- Category:EC 4.2.1
Category:EC 4.3 (carbon–nitrogen lyases)
- Category:EC 4.3.1
Category:EC 4.4 (carbon–sulfur lyases)
- Category:EC 4.4.1
Category:EC 4.5 (carbon–halide lyases)
- Category:EC 4.5.1
Category:EC 4.6 (phosphorus–oxygen lyases)
- Category:EC 4.6.1
Category:Isomerases (EC 5) (Isomerase)
Category:EC 5.1 (racemases and epimerases)
- Category:EC 5.1.1
- Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing)
- Serine racemase
- Category:EC 5.1.2
- Mandelate racemase
- Category:EC 5.1.3
- UDP-glucose 4-epimerase
- Category:EC 5.1.99
- Methylmalonyl CoA epimerase
Category:EC 5.2 (cis-trans-isomerases)
- Category:EC 5.2
- FKBP: FKBP1A
- FKBP1B
- FKBP2
- FKBP3
- FKBP4
- FKBP5
- FKBP6
- FKBP8
- FKBP9
- FKBP10
- FKBPL
- Cyclophilin
- Parvulin
- Prolyl isomerase
- 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase
- Beta-carotene isomerase
- Farnesol 2-isomerase
- Furylfuramide isomerase
- Linoleate isomerase
- Maleate isomerase
- Maleylacetoacetate isomerase
- Maleylpyruvate isomerase
- Parvulin
- Photoisomerase
- Prolycopene isomerase
- Prolyl isomerase
- Retinal isomerase
- Retinol isomerase
- Zeta-carotene isomerase
Category:EC 5.3 (intramolecular oxidoreductases)
- Category:EC 5.3.3
- Category:EC 5.3.4
Category:EC 5.4 (intramolecular transferases -- mutases)
- Category:EC 5.4.2
Category:EC 5.5 (intramolecular lyases)
| EC number | Examples |
|---|---|
| EC 5.5.1.1 | Muconate cycloisomerase |
| EC 5.5.1.2 | 3-carboxy-cis,cis-muconate cycloisomerase |
| EC 5.5.1.3 | Tetrahydroxypteridine cycloisomerase |
| EC 5.5.1.4 | Inositol-3-phosphate synthase |
| EC 5.5.1.5 | Carboxy-cis,cis-muconate cyclase |
| EC 5.5.1.6 | Chalcone isomerase |
| EC 5.5.1.7 | Chloromuconate cycloisomerase |
| EC 5.5.1.8 | (+)-bornyl diphosphate synthase |
| EC 5.5.1.9 | Cycloeucalenol cycloisomerase |
| EC 5.5.1.10 | Alpha-pinene-oxide decyclase |
| EC 5.5.1.11 | Dichloromuconate cycloisomerase |
| EC 5.5.1.12 | Copalyl diphosphate synthase |
| EC 5.5.1.13 | Ent-copalyl diphosphate synthase |
| EC 5.5.1.14 | Syn-copalyl-diphosphate synthase |
| EC 5.5.1.15 | Terpentedienyl-diphosphate synthase |
| EC 5.5.1.16 | Halimadienyl-diphosphate synthase |
| EC 5.5.1.17 | (S)-beta-macrocarpene synthase |
| EC 5.5.1.18 | Lycopene epsilon-cyclase |
| EC 5.5.1.19 | Lycopene beta-cyclase |
| EC 5.5.1.20 | Prosolanapyrone-III cycloisomerase |
| EC 5.5.1.n1 | D-ribose pyranase |
| EC 5.5.1.22 | Steroid Delta Isomerase |
Category:EC 5.99 (other isomerases)
- Category:EC 5.99.1
- Topoisomerase (type I: EC 5.99.1.2, type II: EC 5.99.1.3)
Category:Ligases (EC 6) (Ligase)
Category:EC 6.1 (form carbon–oxygen bonds)
Category:EC 6.2 (form carbon–sulfur bonds)
- EC 6.2.1.1: Acetate—CoA ligase
- EC 6.2.1.2: Medium-chain acyl—CoA ligase
- EC 6.2.1.3: Long-chain-fatty-acid—CoA ligase
- EC 6.2.1.4: Succinate—CoA ligase (GDP-forming)
- EC 6.2.1.5: Succinate—CoA ligase (ADP-forming)
- EC 6.2.1.6: Glutarate—CoA ligase
- EC 6.2.1.7: Cholate—CoA ligase
- EC 6.2.1.8: Oxalate—CoA ligase
- EC 6.2.1.9: Malate—CoA ligase
- EC 6.2.1.10: Acid—CoA ligase (GDP-forming)
- EC 6.2.1.11: Biotin—CoA ligase
- EC 6.2.1.12: 4-coumarate—CoA ligase
- EC 6.2.1.13: Acetate—CoA ligase (ADP-forming)
- EC 6.2.1.14: 6-carboxyhexanoate—CoA ligase
- EC 6.2.1.15: Arachidonate—CoA ligase
- EC 6.2.1.16: Acetoacetate—CoA ligase
- EC 6.2.1.17: Propionate—CoA ligase
- EC 6.2.1.18: Citrate—CoA ligase
- EC 6.2.1.19: Long-chain-fatty-acid-luciferin-component ligase
- EC 6.2.1.20: Long-chain-fatty-acid-(acyl-carrier-protein) ligase
- EC 6.2.1.21: Transferred entry: 6.2.1.30
- EC 6.2.1.22: (citrate (pro-3S)-lyase) ligase
- EC 6.2.1.23: Dicarboxylate—CoA ligase
- EC 6.2.1.24: Phytanate—CoA ligase
- EC 6.2.1.25: Benzoate—CoA ligase
- EC 6.2.1.26: o-succinylbenzoate—CoA ligase
- EC 6.2.1.27: 4-hydroxybenzoate—CoA ligase
- EC 6.2.1.28: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate—CoA ligase
- EC 6.2.1.29: Transferred entry: 6.2.1.7
- EC 6.2.1.30: Phenylacetate—CoA ligase
- EC 6.2.1.31: 2-furoate—CoA ligase
- EC 6.2.1.32: Anthranilate—CoA ligase
- EC 6.2.1.33: 4-chlorobenzoate—CoA ligase
- EC 6.2.1.34: Trans-feruloyl-CoA synthase
- EC 6.2.1.35: ACP-SH:acetate ligase
- EC 6.2.1.36: 3-hydroxypropionyl-CoA synthase
- EC 6.2.1.37: 3-hydroxybenzoate—CoA ligase
- EC 6.2.1.38: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
- EC 6.2.1.39: (butirosin acyl-carrier protein)—L-glutamate ligase
- EC 6.2.1.40: 4-hydroxybutyrate-CoA ligase
- EC 6.2.1.41: 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate-CoA ligase
- EC 6.2.1.42: 3-oxocholest-4-en-26-oate-CoA ligase
- EC 6.2.1.43: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate-CoA ligase
- EC 6.2.1.44: 3-(methylthio)propionyl-CoA ligase
- EC 6.2.1.45: E1 ubiquitin-activating enzyme
- EC 6.2.1.46: L-allo-isoleucine--holo-CmaA peptidyl-carrier protein ligase
- EC 6.2.1.47: Medium-chain-fatty-acid-(acyl-carrier-protein) ligase
- EC 6.2.1.48: Carnitine-CoA ligase
- EC 6.2.1.49: Long-chain fatty acid adenylyltransferase FadD28
- EC 6.2.1.50: 4-hydroxybenzoate adenylyltransferase FadD22
- EC 6.2.1.51: 4-hydroxyphenylalkanoate adenylyltransferase FadD29
- EC 6.2.1.52: L-firefly luciferin-CoA ligase
- EC 6.2.1.53: L-proline-L-prolyl-carrier protein ligase
- EC 6.2.1.54: D-alanine-D-alanyl-carrier protein ligase
- EC 6.2.1.55: E1 SAMP-activating enzyme
Category:EC 6.3 (form carbon–nitrogen bonds)
Category:EC 6.4 (form carbon–carbon bonds)
Category:EC 6.5 (form phosphoric ester bonds)
Category:EC 6.6 (form nitrogen–metal bonds)
See also
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.