MELTF
Identifiers
AliasesMELTF, CD228, MAP97, MTF1, MTf, MFI2, melanotransferrin
External IDsOMIM: 155750 MGI: 1353421 HomoloGene: 4335 GeneCards: MELTF
Orthologs
SpeciesHumanMouse
Entrez

4241

30060

Ensembl

ENSG00000163975

ENSMUSG00000022780

UniProt

P08582

Q9R0R1

RefSeq (mRNA)

NM_005929
NM_033316

NM_013900

RefSeq (protein)

NP_005920
NP_201573

NP_038928

Location (UCSC)Chr 3: 196.98 – 197.03 MbChr 16: 31.7 – 31.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.[5] It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000163975 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022780 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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