| mir-612 | |
|---|---|
| Identifiers | |
| Symbol | mir-612 |
| Rfam | RF00959 |
| miRBase family | MIPF0000464 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota |
| PDB structures | PDBe |
mir-612 microRNA is a short non-coding RNA molecule belonging both to the family of microRNAs and to that of small interfering RNAs (siRNAs). MicroRNAs function to regulate the expression levels of other genes by several mechanisms, whilst siRNAs are involved primarily with the RNA interference (RNAi) pathway. siRNAs have been linked through some members to the regulation of cancer cell growth, specifically in prostate adenocarcinoma.
miR-612 and p53
The microRNA miR-2185 has a strong inhibitory effect on the tumour suppressor protein p53, acting through targeting its 3'UTR. MiR-612 is of the same seed sequence as miR-2185 but, despite this, is yet to be identified as a p53 inhibitor.[1]
See also
References
- ↑ Tian S, Huang S, Wu S, Guo W, Li J, He X (2010). "MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3' untranslated region". Biochem Biophys Res Commun. 396 (2): 435–9. doi:10.1016/j.bbrc.2010.04.112. PMID 20417621.
Further reading
- Jian, P.; Li, Z.; Fang, T.; Jian, W.; Zhuan, Z.; Mei, L.; Yan, W.; Jian, N. (2011). "Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663". Journal of Hematology & Oncology. 4: 20. doi:10.1186/1756-8722-4-20. PMC 3094392. PMID 21518431.
External links
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