mir-632
Identifiers
Symbolmir-632
RfamRF01010
miRBase familyMIPF0000527
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology mir-632 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-632 and MDS

miR-632 has been identified as one of three key miRNAs associated with the anti-ageing myelodysplastic syndromes (MDS). In particular, its levels show high discrimination between MDS and normal controls, and expression is decreased in MDS.[1] In this way it can be used as a potential diagnostic marker for MDS.

DNAJB6 protein

miR-632 targets the coding region of the DNAJB6 protein, a member of the Heat Shock Protein 40 (HSP40) family which shows constitutive expression. DNAJB6 is known to be a negative regulator of tumour progression in breast cancer and its levels are compromised in advanced tumour progression. miR-632 has been linked to be downregulation of DNAJB6 and is capable of silencing both spliced variants of this protein.[2] It is currently unknown whether miR-632 may be just one of many negative regulators controlling DNAJB6 levels.

See also

References

  1. Erdogan B, Facey C, Qualtieri J, Tedesco J, Rinker E, Isett RB, et al. (2011). "Diagnostic microRNAs in myelodysplastic syndrome". Exp Hematol. 39 (9): 915–926.e2. doi:10.1016/j.exphem.2011.06.002. PMID 21703983.
  2. Mitra A, Rostas JW, Dyess DL, Shevde LA, Samant RS (2012). "Micro-RNA-632 downregulates DNAJB6 in breast cancer". Lab Invest. 92 (9): 1310–7. doi:10.1038/labinvest.2012.87. PMC 3660857. PMID 22710984.


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