NMBR
Identifiers
AliasesNMBR, BB1, NMB-R, neuromedin B receptor, BB1R, BRS1
External IDsOMIM: 162341 MGI: 1100525 HomoloGene: 20560 GeneCards: NMBR
Orthologs
SpeciesHumanMouse
Entrez

4829

18101

Ensembl

ENSG00000135577

ENSMUSG00000019865

UniProt

P28336

O54799

RefSeq (mRNA)

NM_002511
NM_001324307
NM_001324308

NM_008703

RefSeq (protein)

NP_001311236
NP_001311237
NP_002502

NP_032729

Location (UCSC)Chr 6: 142.06 – 142.15 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The neuromedin B receptor (NMBR), now known as BB1 [4] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.[5] In humans, this protein is encoded by the NMBR gene.

Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000135577 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Bombesin Receptors: BB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
  5. Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT (1995). "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. PMID 7838118.
  6. "Entrez Gene: NMBR neuromedin B receptor".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.