OR3A1
Identifiers
AliasesOR3A1, OLFRA03, OR17-40, OR17-82, OR40, olfactory receptor family 3 subfamily A member 1, olfactory receptor family 3 subfamily A member 1 (gene/pseudogene)
External IDsMGI: 3030236 HomoloGene: 1915 GeneCards: OR3A1
Orthologs
SpeciesHumanMouse
Entrez

4994

258703

Ensembl

ENSG00000180090

ENSMUSG00000070379

UniProt

P47881

Q8VFX8

RefSeq (mRNA)

NM_002550

NM_146708

RefSeq (protein)

NP_002541

NP_666919

Location (UCSC)Chr 17: 3.29 – 3.3 MbChr 11: 74.04 – 74.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 3A1 is a protein that in humans is encoded by the OR3A1 gene.[5][6][7]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[7]

Ligands

OR3A1 is activated by helional and the closely related molecule heliotropylacetone.[8] Other compounds including piperonal, safrole, and vanillin completely failed to activate OR3A1.

Agonists:

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000180090 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070379 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Glusman G, Clifton S, Roe B, Lancet D (October 1996). "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity". Genomics. 37 (2): 147–60. doi:10.1006/geno.1996.0536. PMID 8921386.
  6. Crowe ML, Perry BN, Connerton IF (March 1996). "Olfactory receptor-encoding genes and pseudogenes are expressed in humans". Gene. 169 (2): 247–9. doi:10.1016/0378-1119(95)00849-7. PMID 8647456.
  7. 1 2 "Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1".
  8. 1 2 3 Sanz G, Schlegel C, Pernollet JC, Briand L (January 2005). "Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism". Chemical Senses. 30 (1): 69–80. doi:10.1093/chemse/bji002. PMID 15647465.
  9. 1 2 3 Jacquier V, Pick H, Vogel H (April 2006). "Characterization of an extended receptive ligand repertoire of the human olfactory receptor OR17-40 comprising structurally related compounds". Journal of Neurochemistry. 97 (2): 537–44. doi:10.1111/j.1471-4159.2006.03771.x. PMID 16539658. S2CID 22179276.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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