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Formula | C22H23NS |
Molar mass | 333.49 g·mol−1 |
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Tropatepine (brand name Lepticur) is an anticholinergic used as an antiparkinsonian agent.[1]
Synthesis
The Grignard reaction between 3-Chlorotropane, CID:21122177 (1) and Dibenzo[b,e]thiepin-11(6H)-one [1531-77-7] (2) followed by dehydration to olefin completed the synthesis of Tropatepine (3). (2)
See also
References
- ↑ Celsis P, Montastruc JL, Rascol O, Senard JM, Marc-Vergnes JP, Rascol A (July 1989). "Effect of tropatepine, an anticholinergic drug, on regional cerebral blood flow in patients with Parkinson's disease". Journal of Neurology, Neurosurgery, and Psychiatry. 52 (7): 917–8. doi:10.1136/jnnp.52.7.917. PMC 1031949. PMID 2769291.
- ↑ DE1952206 idem J Boissier, R Ratouis, U.S. Patent 3,725,415 (1973 to Ind Pour La Fab Antibiotiques).
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