3CLpro-1

3CLpro-1是一种与芦平曲韦相关的抗病毒药物，作为3C样蛋白酶抑制剂，最初开发用于治疗人类肠病毒71型。它是作为病毒酶3C样蛋白酶抑制剂开发的众多化合物中最有效的一种蛋白酶，体外IC50为200nM。它还显示出对SARS和MERS等冠状病毒疾病的活性，并且正在研究作为病毒性疾病COVID-19的潜在治疗剂。病毒性疾病COVID-19的治疗剂。[1][2][3][4][5][6][7]

3CLpro-1
臨床資料
商品名3CLpro-1
法律規範狀態
法律規範
  • 美：Investigational drug
识别
  • (2S)-2-[[(E)-3-(4-chloro-2-fluorophenyl)prop-2-enoyl]amino]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-3-phenylpropanamide
CAS号2409054-43-7
PubChem CID
ChemSpider
ChEMBL
化学
化学式C25H25ClFN3O4
摩尔质量640.8
3D模型（JSmol）
  • C1CNC(=O)[C@@H]1C[C@@H](C=O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)/C=C/C3=C(C=C(C=C3)Cl)F
  • InChI=1S/C25H25ClFN3O4/c26-19-8-6-17(21(27)14-19)7-9-23(32)30-22(12-16-4-2-1-3-5-16)25(34)29-20(15-31)13-18-10-11-28-24(18)33/h1-9,14-15,18,20,22H,10-13H2,(H,28,33)(H,29,34)(H,30,32)/b9-7+/t18-,20-,22-/m0/s1
  • Key:HXAHMXYAYHWWRI-ZCTWNQIISA-N

另见

参考资料
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