GRL-0617

**GRL-0617**
识别
	IUPAC命名法 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide; ;
CAS号	1093070-16-6
PubChem CID	24941262;
IUPHAR/BPS	11078;
DrugBank	DB08656;
ChemSpider	24617535;
UNII	GRL-0617;
ChEBI	CHEBI:167176;
ChEMBL	ChEMBL549695;
化学
化学式	C20H20N2O
摩尔质量	304.39 g·mol−1
3D模型（JSmol）	交互式图像;
	SMILES CC1=C(C=C(C=C1)N)C(=O)N[C@H](C)C2=CC=CC3=CC=CC=C32;
	InChI InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1; Key:UVERBUNNCOKGNZ-CQSZACIVSA-N;

GRL-0617是一种药物，是最早被发现可作为木瓜蛋白酶样蛋白酶的选择性小分子抑制剂的化合物之一，它可在某些致病病毒（包括冠状病毒 SARS-CoV-2）中发现。它已被证明可以在体外抑制病毒复制。[1][2][3][4]

参见

Shin D, Mukherjee R, Grewe D, Bojkova D, Baek K, Bhattacharya A, et al. . Nature. November 2020, 587 (7835): 657–662. Bibcode:2020Natur.587..657S. PMC 7116779 . PMID 32726803. doi:10.1038/s41586-020-2601-5.
Hajbabaie R, Harper MT, Rahman T. (PDF). Molecules. February 2021, 26 (4): 1134 [2022-12-12]. PMC 7924369 . PMID 33672721. doi:10.3390/molecules26041134 . （原始内容存档 (PDF)于2022-12-12）.
Lim CT, Tan KW, Wu M, Ulferts R, Armstrong LA, Ozono E, et al. . The Biochemical Journal. July 2021, 478 (13): 2517–2531. PMC 8286840 . PMID 34198325. doi:10.1042/BCJ20210244.
Xiang R, Yu Z, Wang Y, Wang L, Huo S, Li Y, et al. . Acta Pharmaceutica Sinica. B. July 2021. PMC 8260826 . PMID 34249607. doi:10.1016/j.apsb.2021.06.016.

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