SIB-1757

SIB-1757是一种有机化合物,分子式C12H11N3O,带有偶氮基团,可作为代谢型谷氨酸受体亚型mGluR5受体拮抗剂[1],在动物实验中存在抗痛觉过敏作用[2]

SIB-1757
识别
  • 6-methyl-2-(phenylazo)-3-pyridinol
CAS号31993-01-8  checkY
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
ECHA InfoCard100.164.315
化学
化学式C12H11N3O
摩尔质量213.24 g·mol−1
3D模型(JSmol
  • Oc1ccc(C)nc1\N=N\c2ccccc2
  • InChI=1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+
  • Key:LOCPVWIREQIGNQ-CCEZHUSRSA-N

参考文献

  1. Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Veliçelebi G, Johnson EC. . The Journal of Pharmacology and Experimental Therapeutics. July 1999, 290 (1): 170–81. PMID 10381773.
  2. Dogrul A, Ossipov MH, Lai J, Malan TP, Porreca F. . Neuroscience Letters. October 2000, 292 (2): 115–8. PMID 10998562. doi:10.1016/S0304-3940(00)01458-0.
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