LGR4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLGR4, BNMD17, GPR48, leucine-rich repeat containing G protein-coupled receptor 4, leucine rich repeat containing G protein-coupled receptor 4, DPSL
External IDsOMIM: 606666 MGI: 1891468 HomoloGene: 10226 GeneCards: LGR4
Orthologs
SpeciesHumanMouse
Entrez

55366

107515

Ensembl

ENSG00000205213

ENSMUSG00000050199

UniProt

Q9BXB1

A2ARI4

RefSeq (mRNA)

NM_018490
NM_001346432

NM_172671

RefSeq (protein)

NP_001333361
NP_060960

NP_766259

Location (UCSC)Chr 11: 27.37 – 27.47 MbChr 2: 109.75 – 109.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 4 is a protein that in humans is encoded by the LGR4 gene.[5][6] LGR4 is known to have a role in the development of the male reproductive tract, eyelids, hair and bone.

Mutations in this gene have been associated to osteoporosis (doi:10.1038/nature12124).

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000205213 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050199 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Loh ED, Broussard SR, Liu Q, Copeland NG, Gilbert DJ, Jenkins NA, Kolakowski LF Jr (Aug 2000). "Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping". Cytogenet Cell Genet. 89 (1–2): 2–5. doi:10.1159/000015576. PMID 10894923. S2CID 607389.
  6. "Entrez Gene: LGR4 leucine-rich repeat-containing G protein-coupled receptor 4".

Further reading

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