chemokine (C-C motif) ligand 25
Identifiers
SymbolCCL25
Alt. symbolsSCYA25, TECK, Ckb15
NCBI gene6370
HGNC10624
OMIM602565
RefSeqNM_005624
UniProtO15444
Other data
LocusChr. 19 p13.2
Search for
StructuresSwiss-model
DomainsInterPro

Chemokine (C-C motif) ligand 25 (CCL25) is a small cytokine belonging to the CC chemokine family that is also known as TECK (Thymus-Expressed Chemokine). CCL25 is believed to play a role in the development of T-cells.[1] It is chemotactic for thymocytes, macrophages, and dendritic cells. CCL25 elicits its effects by binding to the chemokine receptor CCR9.[2][3] Human CCL25 is produced as a protein precursor containing 151 amino acids. The gene for CCL25 (scya25) is located on human chromosome 19.[4]

References

  1. ↑ Vacari et al., TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity, 1997, 7:291-301.
  2. ↑ Zaballos et al., Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol., 1999, 162:5671-5675.
  3. ↑ Gosling et al., Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000, 164:2851-6.
  4. ↑ Nomiyama et al., The human CC chemokine TECK (SCYA25) maps to chromosome 19p13.2. Genomics, 1998, 51:311-312.



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