CXCL6

Search for
Structures	Swiss-model
Domains	InterPro

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
Identifiers
Symbol	CXCL6
Alt. symbols	SCYB6, GCP-2, CKA-3
NCBI gene	6372
HGNC	10643
OMIM	138965
RefSeq	NM_002993
UniProt	P80162
Other data
Locus	Chr. 4 q21
Structures
Search for
Structures	Swiss-model
Domains	InterPro

CXCL6
Identifiers
Aliases	CXCL6, CKA-3, GCP-2, GCP2, SCYB6, C-X-C motif chemokine ligand 6
External IDs	OMIM: 138965 MGI: 1096868 HomoloGene: 88671 GeneCards: CXCL6
Gene location (Human)
Chr.	Chromosome 4 (human)
End	73,849,064 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	90,909,483 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; palpebral conjunctiva; ; spleen; ; islet of Langerhans; ; parietal pleura; ; jejunal mucosa; ; sperm; ; gallbladder; ; periodontal fiber; ; germinal epithelium;
	Top expressed in
	right lobe of liver; ; cervix; ; trachea; ; respiratory epithelium; ; olfactory epithelium; ; conjunctival fornix; ; right lung lobe; ; facial motor nucleus; ; meninges; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; CXCR chemokine receptor binding; heparin binding; chemokine activity; protein binding;
Cellular component	extracellular region; extracellular space;
Biological process	chemotaxis; cell-cell signaling; chemokine-mediated signaling pathway; regulation of cell population proliferation; defense response to bacterium; signal transduction; neutrophil mediated immunity; defense response; positive regulation of neutrophil chemotaxis; neutrophil chemotaxis; neutrophil activation; antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide; inflammatory response; immune response; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; leukocyte homeostasis; leukocyte chemotaxis; response to lipopolysaccharide; regulation of chemokine production; regulation of neutrophil mediated killing of gram-negative bacterium;
	Sources:Amigo / QuickGO
Orthologs
	6372
	20311
	ENSG00000124875
	ENSMUSG00000029371
	P80162
	P50228
	NM_002993
	NM_009141
	NP_002984
	NP_033167
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes.^[5]^[6] It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.^[6] The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124875 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J (1993). "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines". Biochemistry. 32 (38): 10170–7. doi:10.1021/bi00089a037. PMID 8399143.
1 2 Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J (1997). "Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties". Biochemistry. 36 (9): 2716–23. doi:10.1021/bi961999z. PMID 9054580.
↑ Modi W, Chen Z (1998). "Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids". Genomics. 47 (1): 136–9. doi:10.1006/geno.1997.5100. PMID 9465307.
↑ O'Donovan N, Galvin M, Morgan J (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124875 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J (1993). "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines". Biochemistry. 32 (38): 10170–7. doi:10.1021/bi00089a037. PMID 8399143.

[wuyts-6] 1 2 Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J (1997). "Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties". Biochemistry. 36 (9): 2716–23. doi:10.1021/bi961999z. PMID 9054580.

[7] Modi W, Chen Z (1998). "Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids". Genomics. 47 (1): 136–9. doi:10.1006/geno.1997.5100. PMID 9465307.

[8] O'Donovan N, Galvin M, Morgan J (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

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