3,4-Dihydroxystyrene

3,4-Dihydroxystyrene
Clinical data
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 4-Ethenylbenzene-1,2-diol;
CAS Number	6053-02-7 ;
PubChem CID	151398;
ChemSpider	133430 ;
UNII	28C0I29E70;
KEGG	C06224 ;
CompTox Dashboard (EPA)	DTXSID20209275 ;
Chemical and physical data
Formula	C8H8O2
Molar mass	136.150 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1ccc(\C=C)cc1O;
	InChI InChI=1S/C8H8O2/c1-2-6-3-4-7(9)8(10)5-6/h2-5,9-10H,1H2 ; Key:FBTSUTGMWBDAAC-UHFFFAOYSA-N ;
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3,4-Dihydroxystyrene (DHS) is a centrally-acting inhibitor of the enzyme phenylalanine hydroxylase (PH).^[1] It is likely that DHS and other PH inhibitors will never have clinical applications on account of their capacity for inducing hyperphenylalaninemia and phenylketonuria.

References

↑ Koizumi S, Matsushima Y, Nagatsu T, Iinuma H, Takeuchi T, Umezawa H (September 1984). "3,4-dihydroxystyrene, a novel microbial inhibitor for phenylalanine hydroxylase and other pteridine-dependent monooxygenases". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 789 (2): 111–8. doi:10.1016/0167-4838(84)90194-8. PMID 6148105.

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