Clotizolam
Legal status
Legal status
Identifiers
  • 2-Chloro-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H10Cl2N4S
Molar mass349.23 g·mol−1
3D model (JSmol)
Melting point205 °C (401 °F)
  • CC1=NN=C2N1C3=C(C=C(S3)Cl)C(=NC2)C4=CC=CC=C4Cl
  • InChI=1S/C15H10Cl2N4S/c1-8-19-20-13-7-18-14(9-4-2-3-5-11(9)16)10-6-12(17)22-15(10)21(8)13/h2-6H,7H2,1H3
  • Key:CHGXYVPOFYZWRH-UHFFFAOYSA-N

Clotizolam (Ro11-1465) is a thienotriazolodiazepine derivative first invented in the 1970s, which in more recent years has been sold as a designer drug. As with other related thienotriazolodiazepines, it produces sedative, anxiolytic, anticonvulsant and muscle relaxant effects,[1] and also acts as an inhibitor of platelet-activating factor (PAF).[2]

See also

References

  1. US 4155913, Hellerbach J, Zeller P, Binder D, Hromatka O, "Thienotriazolodiazepine derivatives", issued 22 May 1979, assigned to Hoffmann La Roche Inc.
  2. Tahara T, Mikashima H, Terasawa M, Maruyama Y (May 1987). "PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines". Chemical & Pharmaceutical Bulletin. 35 (5): 2119–21. doi:10.1248/cpb.35.2119. PMID 3664818. S2CID 27564672.


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