transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Identifiers
SymbolTFAP2A
Alt. symbolsTFAP2, AP2TF
NCBI gene7020
HGNC11742
OMIM107580
RefSeqNM_003220
UniProtP05549
Other data
LocusChr. 6 p22.3
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StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Identifiers
SymbolTFAP2B
Alt. symbolsAP2-B
NCBI gene7021
HGNC11743
OMIM601601
RefSeqNM_003221
UniProtQ92481
Other data
LocusChr. 6 p12
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StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
Identifiers
SymbolTFAP2C
NCBI gene7022
HGNC11744
OMIM601602
RefSeqNM_003222
UniProtQ92754
Other data
LocusChr. 20 q13.2
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StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
Identifiers
SymbolTFAP2D
Alt. symbolsTFAP2BL1
NCBI gene83741
HGNC15581
OMIM610161
RefSeqNM_172238
UniProtQ7Z6R9
Other data
LocusChr. 6 p12.3
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StructuresSwiss-model
DomainsInterPro
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
Identifiers
SymbolTFAP2E
Alt. symbolsAP2E
NCBI gene339488
HGNC30774
RefSeqNM_178548
UniProtQ6VUC0
Other data
LocusChr. 1 p34.3
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DomainsInterPro

Activating Protein 2 (AP-2) is a family of closely related transcription factors[1][2] which plays a critical role in regulating gene expression during early development.[3]

References

  1. ↑ Williams T, Tjian R (1991). "Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins". Science. 251 (4997): 1067–71. Bibcode:1991Sci...251.1067W. doi:10.1126/science.1998122. PMID 1998122.
  2. ↑ Williams T, Tjian R (1991). "Analysis of the DNA-binding and activation properties of the human transcription factor AP-2". Genes Dev. 5 (4): 670–82. doi:10.1101/gad.5.4.670. PMID 2010091.
  3. ↑ Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). "Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control". Gene. 260 (1–2): 1–12. doi:10.1016/S0378-1119(00)00454-6. PMID 11137286.


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