EGR4

EGR4
Identifiers
Aliases	EGR4, NGFI-C, NGFIC, PAT133, early growth response 4, Early growth response protein 4, AT133
External IDs	OMIM: 128992 MGI: 99252 HomoloGene: 1485 GeneCards: EGR4
Gene location (Human)
Chr.	Chromosome 2 (human)
End	73,293,701 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	85,490,571 bp
RNA expression pattern
	Top expressed in
	Region I of hippocampus proper; ; endothelial cell; ; pancreatic ductal cell; ; putamen; ; Brodmann area 46; ; nucleus accumbens; ; entorhinal cortex; ; orbitofrontal cortex; ; middle temporal gyrus; ; parietal lobe;
	Top expressed in
	superior frontal gyrus; ; urethra; ; female urethra; ; male urethra; ; spermatocyte; ; cerebellar cortex; ; hippocampus proper; ; olfactory bulb; ; basal forebrain; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; metal ion binding; nucleic acid binding; DNA-binding transcription activator activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of cell population proliferation; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; cellular response to growth factor stimulus;
	Sources:Amigo / QuickGO
Orthologs
	1961
	13656
	ENSG00000135625
	ENSMUSG00000071341
	Q05215
	Q9WUF2
	NM_001965
	NM_020596
	NP_001956
	NP_065621
	Wikidata
View/Edit Human	View/Edit Mouse

Early growth response protein 4 (EGR-4), also known as AT133, is a protein that in humans is encoded by the EGR4 gene.^[5]

EGR-4 is a member of the early growth response (EGF) family of zinc finger transcription factors.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135625 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071341 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: early growth response 4".

Crosby SD, Veile RA, Donis-Keller H, et al. (1992). "Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C". Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4739–43. Bibcode:1992PNAS...89.4739C. doi:10.1073/pnas.89.10.4739. PMC 49159. PMID 1584812.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Müller HJ, Skerka C, Bialonski A, Zipfel PF (November 1991). "Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor-induced genes with almost identical zinc-finger domains". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10079–83. Bibcode:1991PNAS...8810079M. doi:10.1073/pnas.88.22.10079. PMC 52871. PMID 1658795.
Decker EL, Nehmann N, Kampen E, et al. (2003). "Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression". Nucleic Acids Res. 31 (3): 911–21. doi:10.1093/nar/gkg186. PMC 149206. PMID 12560487.
Liu BC, Zhang J, Wang L, et al. (2010). "No association between EGR gene family polymorphisms and schizophrenia in the Chinese population". Prog. Neuropsychopharmacol. Biol. Psychiatry. 34 (3): 506–9. doi:10.1016/j.pnpbp.2010.02.005. PMID 20144677. S2CID 207409159.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Holst C, Skerka C, Lichter P, et al. (1993). "Genomic organization, chromosomal localization and promoter function of the human zinc-finger gene pAT133". Hum. Mol. Genet. 2 (4): 367–72. doi:10.1093/hmg/2.4.367. PMID 8504297.
Crosby SD, Puetz JJ, Simburger KS, et al. (1991). "The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family". Mol. Cell. Biol. 11 (8): 3835–41. doi:10.1128/MCB.11.8.3835. PMC 361165. PMID 2072895.
Hadziselimovic F, Hadziselimovic NO, Demougin P, et al. (2009). "EGR4 is a master gene responsible for fertility in cryptorchidism". Sex Dev. 3 (5): 253–63. doi:10.1159/000249147. PMID 19828938.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135625 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071341 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: early growth response 4".

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References

Further reading