POU4F2
Identifiers
Aliases	POU4F2, BRN3.2, BRN3B, Brn-3b, POU class 4 homeobox 2
External IDs	OMIM: 113725 MGI: 102524 HomoloGene: 20959 GeneCards: POU4F2
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.22 Start 146,638,893 bp[1] End 146,642,474 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C1 Start 79,159,639 bp[2] End 79,163,274 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte pons pancreatic ductal cell sensory ganglion trigeminal ganglion ventral tegmental area medulla oblongata superior vestibular nucleus testicle renal cortex Top expressed in trigeminal ganglion superior colliculus morula otolith organ inferior colliculus utricle ganglion cell layer pontine nuclei neural tube lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific transcription coactivator activity transcription corepressor activity promoter-specific chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific p53 binding Cellular component nucleoplasm nucleus nuclear speck cytoplasm plasma membrane membrane transcription regulator complex Biological process regulation of transcription, DNA-templated axonogenesis neuromuscular process controlling balance sensory perception of sound transcription, DNA-templated MAPK cascade axon guidance retina development in camera-type eye positive regulation of cell differentiation spermatogenesis neuron differentiation axon extension intracellular estrogen receptor signaling pathway retinal ganglion cell axon guidance regulation of signal transduction by p53 class mediator transcription by RNA polymerase II negative regulation of DNA-binding transcription factor activity positive regulation of transcription by RNA polymerase II positive regulation of programmed cell death negative regulation of cell differentiation positive regulation of osteoclast differentiation positive regulation of axon extension regulation of DNA-binding transcription factor activity cellular response to cytokine stimulus cellular response to estradiol stimulus intrinsic apoptotic signaling pathway by p53 class mediator regulation of retinal ganglion cell axon guidance negative regulation of amacrine cell differentiation dorsal root ganglion development positive regulation of transcription regulatory region DNA binding apoptotic process multicellular organism development cell differentiation negative regulation of transcription by RNA polymerase II heart development regulation of gene expression positive regulation of cardiac muscle cell apoptotic process cellular response to insulin stimulus positive regulation of glucose import cellular response to oxygen levels negative regulation of adipose tissue development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5458 18997 Ensembl ENSG00000151615 ENSMUSG00000031688 UniProt Q12837 Q63934 RefSeq (mRNA) NM_004575 NM_138944 RefSeq (protein) NP_004566 NP_620394 Location (UCSC) Chr 4: 146.64 – 146.64 Mb Chr 8: 79.16 – 79.16 Mb PubMed search [3] [4]
Wikidata
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POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.^[5][6]

Function

POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM]^[6]

Interactions

POU4F2 has been shown to interact with Estrogen receptor alpha.^[7]

See also

• BRN-3

References

Further reading

External links

• POU4F2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.