FOXI3

FOXI3
Identifiers
Aliases	FOXI3, forkhead box I3
External IDs	OMIM: 612351 MGI: 3511278 HomoloGene: 52949 GeneCards: FOXI3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	88,452,693 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	70,938,050 bp
RNA expression pattern
	Top expressed in
	placenta; ; ganglionic eminence; ; anterior pituitary; ; skin of abdomen; ; renal cortex; ; gonad; ; testicle;
	Top expressed in
	pharyngeal pouch; ; cervical loop; ; stellate reticulum; ; hair follicle; ; salivary gland; ; surface ectoderm; ; lens; ; morula; ; lip; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	344167
	232077
	ENSG00000214336
	ENSMUSG00000055874
	A8MTJ6
	n/a
	NM_001135649
	NM_001101464
	NP_001129121
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Forkead box I3 (FOXI3) is a protein that in humans is encoded by the FOXI3 gene. FOXI3 is a forkhead box transcription factor that is expressed in the development of hair and teeth. One of its mutations is a dominant allele responsible for the heterozygous Hh hairless trait in dogs. It was identified in 2008.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000214336 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055874 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Drögemüller C, Karlsson EK, Hytönen MK, Perloski M, Dolf G, Sainio K, et al. (September 2008). "A mutation in hairless dogs implicates FOXI3 in ectodermal development". Science. 321 (5895): 1462. Bibcode:2008Sci...321.1462D. doi:10.1126/science.1162525. PMID 18787161. S2CID 206514824.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000214336 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055874 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Drögemüller C, Karlsson EK, Hytönen MK, Perloski M, Dolf G, Sainio K, et al. (September 2008). "A mutation in hairless dogs implicates FOXI3 in ectodermal development". Science. 321 (5895): 1462. Bibcode:2008Sci...321.1462D. doi:10.1126/science.1162525. PMID 18787161. S2CID 206514824.

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See also

References