DLX4
Identifiers
AliasesDLX4, BP1, DLX7, DLX8, DLX9, Dlx-4, OFC15, distal-less homeobox 4
External IDsOMIM: 601911 MGI: 94904 HomoloGene: 7292 GeneCards: DLX4
Orthologs
SpeciesHumanMouse
Entrez

1748

13394

Ensembl

ENSG00000108813

ENSMUSG00000020871

UniProt

Q92988

P70436

RefSeq (mRNA)

NM_001934
NM_138281

NM_007867

RefSeq (protein)

NP_001925
NP_612138

NP_031893

Location (UCSC)Chr 17: 49.97 – 49.97 MbChr 11: 95.03 – 95.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.[5]

Function

Many vertebrate homeobox-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform (BP1) functions as a repressor of the beta-globin gene while the other isoform lacks that function.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000108813 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020871 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: DLX4 distal-less homeobox 4".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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