SOX4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSOX4, EVI16, SRY-box 4, SRY-box transcription factor 4, CSS10
External IDsOMIM: 184430 MGI: 98366 HomoloGene: 2338 GeneCards: SOX4
Orthologs
SpeciesHumanMouse
Entrez

6659

20677

Ensembl

ENSG00000124766

ENSMUSG00000076431

UniProt

Q06945

Q06831

RefSeq (mRNA)

NM_003107

NM_009238

RefSeq (protein)

NP_003098

NP_033264

Location (UCSC)Chr 6: 21.59 – 21.6 MbChr 13: 29.13 – 29.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.[5][6][7]

Function

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.[7]

Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.[8]

Clinical significance

A genomic region close to the SOX4 gene has been associated with endometrial cancer development.[9][10]

Interactions

SOX4 has been shown to interact with SDCBP.[11]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000124766 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000076431 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN (January 1994). "Characterization and mapping of the human SOX4 gene". Mammalian Genome. 4 (10): 577–84. doi:10.1007/BF00361388. PMID 8268656. S2CID 12096721.
  6. Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (October 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenetics and Cell Genetics. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625. S2CID 46849443.
  7. 1 2 "Entrez Gene: SOX4 SRY (sex determining region Y)-box 4".
  8. Smith E, Sigvardsson M (June 2004). "The roles of transcription factors in B lymphocyte commitment, development, and transformation". Journal of Leukocyte Biology. 75 (6): 973–81. doi:10.1189/jlb.1103554. PMID 14982952. S2CID 6805071.
  9. O'Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, et al. (August 2018). "Identification of nine new susceptibility loci for endometrial cancer". Nature Communications. 9 (1): 3166. Bibcode:2018NatCo...9.3166O. doi:10.1038/s41467-018-05427-7. PMC 6085317. PMID 30093612.
  10. Chen MM, O'Mara TA, Thompson DJ, Painter JN, Attia J, Black A, et al. (June 2016). "GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer". Human Molecular Genetics. 25 (12): 2612–2620. doi:10.1093/hmg/ddw092. PMC 5868213. PMID 27008869.
  11. Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ (August 2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science. 293 (5532): 1136–8. doi:10.1126/science.1059157. PMID 11498591. S2CID 28003281.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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